典型文献
Cooperative coordination-mediated multi-component self-assembly of"all-in-one"nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer
文献摘要：
Carrier-free multi-component self-assembled nano-systems have attracted widespread atten-tion owing to their easy preparation,high drug-loading efficiency,and excellent therapeutic efficacy.Herein,MnAs-ICG nanospike was generated by self-assembly of indocyanine green(ICG),manganese ions(Mn2+),and arsenate(AsO43-)based on electrostatic and coordination interactions,effectively inte-grating the bimodal imaging ability of magnetic resonance imaging(MRI)and fluorescence(FL)imaging-guided synergistic therapy of photothermal/chemo/chemodynamic therapy within an"all-in-one"theranostic nano-platform.The as-prepared MnAs-ICG nanospike had a uniform size,well-defined nanospike morphology,and impressive loading capacities.The MnAs-ICG nanospike exhibited sensitive responsiveness to the acidic tumor microenvironment with morphological transformation and dimensional variability,enabling deep penetration into tumor tissue and on-demand release of functional therapeutic components.In vitro and in vivo results revealed that MnAs-ICG nanospike showed synergis-tic tumor-killing effect,prolonged blood circulation and increased tumor accumulation compared to their individual components,effectively resulting in synergistic therapy of photothermal/chemo/chemody-namic therapy with excellent anti-tumor effect.Taken together,this new strategy might hold great prom-ise for rationally engineering multifunctional theranostic nano-platforms for breast cancer treatment.
文献关键词：
中图分类号：
作者姓名：
Xiaojie Chen;Xudong Fan;Yue Zhang;Yinghui Wei;Hangsheng Zheng;Dandan Bao;Hengwu Xu;Ji-Gang Piao;Fanzhu Li;Hongyue Zheng
作者机构：
School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Dermatology&Cosmetology,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine),Hangzhou 310006,China;Department of Pharmacy,Jinhua People's Hospital,Jinhua 321000,China;Academy of Chinese Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China;Libraries of Zhejiang Chinese Medical University,Zhejiang Chinese Medical University,Hangzhou 310053,China
文献出处：
引用格式：
[1]Xiaojie Chen;Xudong Fan;Yue Zhang;Yinghui Wei;Hangsheng Zheng;Dandan Bao;Hengwu Xu;Ji-Gang Piao;Fanzhu Li;Hongyue Zheng-.Cooperative coordination-mediated multi-component self-assembly of"all-in-one"nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer)[J].药学学报（英文版）,2022(09):3710-3725
A类：
nanospike,MnAs,AsO43,chemody,ise
B类：
Cooperative,coordination,mediated,self,assembly,theranostic,guided,synergistic,therapy,against,breast,cancer,Carrier,free,assembled,systems,have,attracted,widespread,atten,owing,their,easy,preparation,high,drug,loading,efficiency,excellent,therapeutic,efficacy,Herein,ICG,was,generated,by,indocyanine,green,manganese,Mn2+,arsenate,electrostatic,interactions,effectively,grating,bimodal,imaging,magnetic,resonance,fluorescence,FL,photothermal,chemodynamic,within,prepared,had,uniform,size,well,defined,morphology,impressive,capacities,exhibited,sensitive,responsiveness,acidic,tumor,microenvironment,morphological,transformation,dimensional,variability,enabling,deep,penetration,into,tissue,demand,release,components,In,vitro,vivo,results,revealed,that,showed,killing,prolonged,blood,circulation,increased,accumulation,compared,individual,resulting,anti,Taken,together,this,new,strategy,might,hold,great,prom,rationally,engineering,multifunctional,platforms,treatment
AB值：
0.526179
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
