典型文献
Supramolecular engineering of cell membrane vesicles for cancer immunotherapy
文献摘要：
The clinical translation of nanomedicines has been strongly hampered by the limitations of delivery vehi-cles,promoting scientists to search for novel nanocarriers.Although cell membrane-based delivery sys-tems have attracted extensive attention,further functionalizations are urgently desired to augment their theranostic functions.We propose a cell-friendly supramolecular strategy to engineer cell membranes utilizing cyclodextrin-based host-guest molecular recognitions to fix the defects arising from chemical and genetic modifications.In this study,the supramolecular cell membrane vesicles(SCMVs)specifically accumulate in tumors,benefiting from tumor-homing capability and the enhanced permeability and retention effect.SCMVs co-delivering indocyanine green and an indoleamine 2,3-dioxygenase inhibitor effectively ablate tumors combining photodynamic therapy and immunotherapy.Driven by host-guest inclusion complexation,SCMVs successfully encapsulate resiquimod to repolarize tumor-associated macrophages into M1 phenotype,synergizing with immune checkpoint blockade therapy.This supramolecular engineering methodology based on noncovalent interactions presents a generalizable and cell-friendly tactic to develop living cell-originated nanomaterials for precise cancer therapy.
文献关键词：
中图分类号：
作者姓名：
Shaolong Qi;Haiyan Zhang;Xueyan Zhang;Xinyang Yu;Yajun Wang;Qian-Fang Meng;Kai Yang;Bing Bai;Rui Tian;Shoujun Zhu;Lang Rao;Feihe Huang;Guocan Yu
作者机构：
Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Department of Chemistry,Tsinghua University,Beijing 100084,China;State Key Laboratory of Supramolecular Structure and Materials,College of Chemistry,Jilin University,Changchun 130012,China;Institute of Biomedical Health Technology and Engineering,Shenzhen Bay Laboratory,Shenzhen 518132,China;State Key Laboratory of Chemical Engineering,Stoddart Institute of Molecular Science,Department of Chemistry,Zhejiang University,Hangzhou 310027,China;ZJU-Hangzhou Global Scientific and Technological Innovation Center,Hangzhou 311215,China;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Center for Molecular Imaging and Translational Medicine School of Public Health,Xiamen University,Xiamen 361102,China
文献出处：
引用格式：
[1]Shaolong Qi;Haiyan Zhang;Xueyan Zhang;Xinyang Yu;Yajun Wang;Qian-Fang Meng;Kai Yang;Bing Bai;Rui Tian;Shoujun Zhu;Lang Rao;Feihe Huang;Guocan Yu-.Supramolecular engineering of cell membrane vesicles for cancer immunotherapy)[J].科学通报（英文版）,2022(18):1898-1909
A类：
functionalizations,recognitions,SCMVs,resiquimod,repolarize
B类：
Supramolecular,engineering,cell,vesicles,cancer,immunotherapy,clinical,translation,nanomedicines,has,been,strongly,hampered,by,limitations,delivery,vehi,promoting,scientists,search,novel,nanocarriers,Although,sys,tems,have,attracted,extensive,attention,further,are,urgently,desired,augment,their,theranostic,functions,We,propose,friendly,supramolecular,strategy,membranes,utilizing,cyclodextrin,host,guest,fix,defects,arising,from,chemical,genetic,modifications,In,this,study,specifically,accumulate,tumors,benefiting,homing,capability,enhanced,permeability,retention,delivering,indocyanine,green,indoleamine,dioxygenase,inhibitor,effectively,ablate,combining,photodynamic,Driven,inclusion,complexation,successfully,encapsulate,associated,macrophages,into,M1,phenotype,synergizing,immune,checkpoint,blockade,This,methodology,noncovalent,interactions,presents,generalizable,tactic,develop,living,originated,nanomaterials,precise
AB值：
0.662787
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
