典型文献
Boron difluoride formazanate dye for high-efficiency NIR-Ⅱfluorescence imaging-guided cancer photothermal therapy
文献摘要：
The small molecular second near-infrared(NIR-Ⅱ,1000-1700 nm)dye-based nanotheranostics can con-currently combine deep-tissue photodiagnosis with in situ phototherapy,which occupies a vital position in the early detection and precise treatment of tumors.However,the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein,we report a novel molecular electron acceptor,boron difluoride formazanate(BDF).Based on BDF,a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-Ⅰ absorp-tion at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm.In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photother-mal therapy of 4T1 tumor-bearing mice.Under 808 nm laser irradiation,tumor growth can be effectively inhibited.This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics.
文献关键词：
中图分类号：
作者姓名：
Hanming Dai;Zijin Cheng;Tian Zhang;Weili Wang;Jinjun Shao;Wenjun Wang;Yongxiang Zhao;Xiaochen Dong;Liping Zhong
作者机构：
Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Nanjing Tech University(NanjingTech),Nanjing 211800,China;School of Physical Science and Information Technology,Liaocheng University,Liaocheng 252059,China;National Center for International Biotargeting Theranostics,Guangxi Key Laboratory of Biotargeting Theranostics,Collaborative Innovation Center for Targeting Tumor Theranostics,Guangxi Medical University,Nanning 530021,China
文献出处：
引用格式：
[1]Hanming Dai;Zijin Cheng;Tian Zhang;Weili Wang;Jinjun Shao;Wenjun Wang;Yongxiang Zhao;Xiaochen Dong;Liping Zhong-.Boron difluoride formazanate dye for high-efficiency NIR-Ⅱfluorescence imaging-guided cancer photothermal therapy)[J].中国化学快报（英文版）,2022(05):2501-2506
A类：
formazanate,photodiagnosis,BDF1005,phototheranostics
B类：
Boron,difluoride,high,efficiency,NIR,fluorescence,imaging,guided,cancer,photothermal,small,molecular,second,near,infrared,nanotheranostics,currently,combine,deep,tissue,situ,phototherapy,which,occupies,vital,position,early,detection,precise,treatment,tumors,However,development,dyes,still,challenging,due,limited,electron,acceptors,cumbersome,synthetic,routes,Herein,report,novel,boron,Based,new,designed,synthesized,strong,absorp,bright,peak,emission,In,vitro,vivo,experiments,demonstrate,that,applied,4T1,bearing,mice,Under,laser,irradiation,growth,effectively,inhibited,This,work,opens,road,exploitation
AB值：
0.511874
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