典型文献
Building multipurpose nano-toolkit by rationally decorating NIR-Ⅱ fluorophore to meet the needs of tumor diagnosis and treatment
文献摘要：
Phototheranostics have attracted tremendous attention in cancer diagnosis and treatment because of the noninvasiveness and promising effectiveness.Developing advanced phototheranostic agents with long emission wavelength,excellent biocompatibility,great tumor-targeting capability,and efficient therapeu-tic effect is highly desirable.However,the mutual constraint between imaging and therapeutic functions usually hinders their wide applications in biomedical field.To balance this contradiction,we herein ratio-nally designed and synthesized three novel tumor-targeted NIR-Ⅱ probes(QR-2PEG321,QR-2PEG1000,and QR-2PEG5000)by conjugating three different chain lengths of PEG onto an integrin αvβ3-targeted NIR-Ⅱ heptamethine cyanine fluorophore,respectively.In virtue of the essential amphiphilic characteristics of PEG polymers,these probes display various degree of aggregation in aqueous buffer accompanying with differential NIR-Ⅱ imaging and photothermal(PTT)therapeutic performance.Both in vitro and in vivo re-sults have demonstrated that probe QR-2PEG5000 has the best NIR-Ⅱ imaging performance with prominent renal clearance,whereas QR-2PEG321 possesses excellent photoacoustic signal as well as PTT effect,which undoubtedly provides a promising toolbox for tumor diagnosis and therapy.We thus envision that these synthesized probes have great potential to be explored as a toolkit for precise diagnosis and treatment of malignant tumors.
文献关键词：
中图分类号：
作者姓名：
Chaoxiang Cui;Jiachen Li;Jing Fang;Yan Zhao;Yuqi Zhang;Shuyue Ye;Anna Wang;Yali Feng;Qiulian Mao;Hongni Qin;Haibin Shi
作者机构：
State Key Laboratory of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X)and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China;Suzhou Industrial Park Institute of Services Outsourcing,Suzhou 215123,China
文献出处：
引用格式：
[1]Chaoxiang Cui;Jiachen Li;Jing Fang;Yan Zhao;Yuqi Zhang;Shuyue Ye;Anna Wang;Yali Feng;Qiulian Mao;Hongni Qin;Haibin Shi-.Building multipurpose nano-toolkit by rationally decorating NIR-Ⅱ fluorophore to meet the needs of tumor diagnosis and treatment)[J].中国化学快报（英文版）,2022(07):3478-3483
A类：
Phototheranostics,noninvasiveness,phototheranostic,2PEG321,2PEG1000,2PEG5000,heptamethine
B类：
Building,multipurpose,nano,toolkit,by,rationally,decorating,NIR,fluorophore,meet,needs,diagnosis,treatment,have,attracted,tremendous,attention,cancer,because,promising,effectiveness,Developing,advanced,agents,long,emission,wavelength,excellent,biocompatibility,great,targeting,capability,efficient,highly,desirable,However,mutual,constraint,between,imaging,therapeutic,functions,usually,hinders,their,wide,applications,biomedical,field,To,balance,this,contradiction,herein,designed,synthesized,three,novel,targeted,probes,QR,conjugating,chain,lengths,onto,integrin,cyanine,respectively,In,virtue,essential,amphiphilic,characteristics,polymers,these,display,various,degree,aggregation,aqueous,buffer,accompanying,differential,photothermal,PTT,performance,Both,vitro,vivo,sults,demonstrated,that,has,best,prominent,renal,clearance,whereas,possesses,photoacoustic,signal,well,which,undoubtedly,provides,toolbox,therapy,We,thus,envision,potential,explored,precise,malignant,tumors
AB值：
0.582934
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