典型文献
Metal-polyphenol-coordinated nanomedicines for Fe(Ⅱ)catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer
文献摘要：
Ferroustherapy has gained great attention for anti-cancer treatment in recent years.Enlightened by temperature-mediated Fenton reaction in industrial waste water removal,we designed a iron-based polyphenol-coordinated nanomedicines for mild hyperthermia-assisted anti-cancer ferroustherapy.In brief,Fe-GA@BSA nanoparticles was synthesized by self-assembly and sorafenib(SRF)was loaded into Fe-GA@BSA to establish Fe-GA@BSA-SRF nanomedicines.The result nanomedicines can induce ferroptosis in cancer cells by accelerating Fenton reaction.And the photothermal effect of Fe-GA@BSA-SRF was used for mild hyperthermia-assisted ferroustherapy.The nanomedicines performs good anti-cancer therapeutic efficacy by inducing the production of ROS and inhibiting glutathione peroxidase 4(GPX4)expression in vitro and in vivo.Besides,the broad absorption of Fe-GA@BSA-SRF in near infrared region endows it with photoacoustic imaging ability.This study provides ideas about rational design on iron-based nanoparticles for anti-cancer ferroustherapy.
文献关键词：
中图分类号：
作者姓名：
Xinying Yu;Tongyi Shang;Guodong Zheng;Hailong Yang;Yuwei Li;Yanjun Cai;Guoxi Xie;Bin Yang
作者机构：
The Sixth Affiliated Hospital,Department of Biomedical Engineering,School of Basic Medical Sciences,Guangzhou Medical University,Guangzhou 511436,China
文献出处：
引用格式：
[1]Xinying Yu;Tongyi Shang;Guodong Zheng;Hailong Yang;Yuwei Li;Yanjun Cai;Guoxi Xie;Bin Yang-.Metal-polyphenol-coordinated nanomedicines for Fe(Ⅱ)catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer)[J].中国化学快报（英文版）,2022(04):1895-1900
A类：
ferroustherapy,Ferroustherapy,Enlightened
B类：
Metal,polyphenol,coordinated,nanomedicines,catalyzed,photoacoustic,imaging,guided,mild,hyperthermia,assisted,against,breast,cancer,has,gained,great,attention,anti,treatment,recent,years,by,temperature,mediated,Fenton,reaction,industrial,waste,water,removal,we,designed,iron,In,brief,GA,BSA,nanoparticles,synthesized,self,assembly,sorafenib,SRF,loaded,into,establish,result,induce,ferroptosis,cells,accelerating,And,photothermal,effect,used,performs,good,therapeutic,efficacy,inducing,production,ROS,inhibiting,glutathione,peroxidase,GPX4,expression,vitro,vivo,Besides,broad,absorption,near,infrared,region,endows,ability,This,study,provides,ideas,about,rational
AB值：
0.528294
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