典型文献
In situ synthesis of red fluorescent gold nanoclusters with enzyme-like activity for oxidative stress amplification in chemodynamic therapy
文献摘要：
Chemodynamic therapy(CDT)has attracted tremendous interest in cancer therapy because it is inde-pendent of oxygen and photoirradiation.However,the therapeutic efficacy of CDT is restricted by in-sufficient H2O2 levels in tumor cells.Herein,employing endogenous GSH as a template and cationic polymeric chitosan(CS)as crosslinker and stabilizer exhibiting easy cell uptake,red luminescent gold nanoclusters(denoted CS-GSH@AuNCs)were successfully synthesized in HeLa cells.The in situ synthe-sized CS-GSH@AuNCs exhibited both superoxidase dismutase(SOD)and peroxidase(POD)-like activity,which could promote the production of H2O2 from superoxide anion radicals(O2·-)and then·OH.The combination of GSH elimination and H2O2 elevation boosted the generation of·OH,which could trigger cancer cell apoptosis and death.The enzyme-like activity of CS-GSH@AuNCs could be effectively activated under acidic conditions,and showed a high killing effect on tumor cells but minimal toxicity to normal cells.The developed GSH consumption and·OH promotion theranostic platform is an innovative route for enhanced CDT by the amplification of oxidative stress.
文献关键词：
中图分类号：
作者姓名：
Wenying Mi;Shuang Tang;Shaoshi Guo;Hejing Li;Na Shao
作者机构：
College of Chemistry,Beijing Normal University,Beijing 100875,China
文献出处：
引用格式：
[1]Wenying Mi;Shuang Tang;Shaoshi Guo;Hejing Li;Na Shao-.In situ synthesis of red fluorescent gold nanoclusters with enzyme-like activity for oxidative stress amplification in chemodynamic therapy)[J].中国化学快报（英文版）,2022(03):1331-1336
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B类：
In,situ,synthesis,red,fluorescent,gold,nanoclusters,enzyme,like,activity,oxidative,stress,amplification,chemodynamic,therapy,Chemodynamic,CDT,has,attracted,tremendous,interest,cancer,because,inde,pendent,oxygen,photoirradiation,However,therapeutic,efficacy,restricted,by,sufficient,H2O2,levels,tumor,cells,Herein,employing,endogenous,GSH,template,cationic,polymeric,chitosan,CS,crosslinker,stabilizer,exhibiting,easy,uptake,luminescent,denoted,AuNCs,were,successfully,synthesized,HeLa,exhibited,both,superoxidase,dismutase,POD,which,could,promote,production,from,superoxide,anion,radicals,then,combination,elimination,elevation,boosted,generation,trigger,apoptosis,death,effectively,activated,under,acidic,conditions,showed,high,killing,but,minimal,toxicity,normal,developed,consumption,promotion,theranostic,platform,innovative,route,enhanced
AB值：
0.629669
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