Compared with traditional photodynamic therapy(PDT),ultrasound(US)triggered sonodynamic ther-apy(SDT)has a wide application prospect in tumor therapy because of its deeper penetration depth.Herein,a novel MnSiO3-Pt(MP)nanocomposite composed of MnSiO3 nanosphere and noble metallic Pt was successfully constructed.After modification with bovine serum albumin(BSA)and chlorine e6(Ce6),the multifunctional nanoplatform MnSiO3-Pt@BSA-Ce6(MPBC)realized the magnetic resonance imaging(MRI)-guided synergetic SDT/chemodynamic therapy(CDT).In this nanoplatform,sonosensitizer Ce6 can generate singlet oxygen(1O2)to kill cancer cells under US irradiation.Meanwhile,the loaded Pt has the ability to catalyze the decomposition of overexpressed hydrogen peroxide(H2O2)in tumor microenviron-ment(TME)to produce oxygen(O2),which can conquer tumor hypoxia and promote the SDT-induced 1O2 production.In addition,MP can degrade in mildly acidic and reductive TME,causing the release of Mn2+.The released Mn2+not only can be used for MRI,but also can generate hydroxyl radical(·OH)for CDT by Fenton-like reaction.The multifunctional nanoplatform MPBC has high biological safety and good anticancer effect,which displays the great latent capacity in biological application.

Fan Jiang;Chunzheng Yang;Binbin Ding;Shuang Liang;Yajie Zhao;Ziyong Cheng;Min Liu;Bengang Xing;Ping'an Ma;Jun Lin

State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China;School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China;Department of Periodontology,Stomatological Hospital,Jilin University,Changchun 130021,China;School of Physical&Mathematical Sciences,Nanyang Technological University,Singapore 639798,Singapore

中国化学快报（英文版）

[1]Fan Jiang;Chunzheng Yang;Binbin Ding;Shuang Liang;Yajie Zhao;Ziyong Cheng;Min Liu;Bengang Xing;Ping'an Ma;Jun Lin-.Tumor microenvironment-responsive MnSiO3-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy)[J].中国化学快报（英文版）,2022(06):2959-2964

MPBC,Mn2+not

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