Lung cancer is the most common malignancy in the world,with a high mortality rate.Nevertheless,therapies to act effectively against lung cancer remain elusive.So far,chemotherapy is still the frontline treatment of lung cancer.Doxorubicin(DOX)is a broad-spectrum anti-tumor drug.However,DOX of-ten has serious side effects and causes multi-drug resistance,which greatly limits its clinical application.In this work,biodegradable methoxy poly(ethylene glycol)-poly(lactic acid)(MPEG-PLA)and cyclo(Arg-Gly-Asp-D-Phe-Lys)(cRGD)polypeptide modified PEG-PLA(cRGD-PEG-PLA)copolymers were used for the co-delivery of curcumin(CUR)and DOX(CUR-DOX/cRGD-M).The particle size of the self-assembled drug-loaded nanomicelle approximately was 27.4 nm and the zeta potential was-2.7 mV.Interestingly,CUR can enhance the uptake of DOX by Lewis lung carcinoma(LL/2)cells.The experimental results in vivo and in vitro showed that CUR-DOX/cRGD-M combination therapy could promote apoptosis of lung can-cer cells,and conspicuously inhibit the tumor growth.Our data indicate that CUR-DOX/cRGD-M will be biodegradable and sustainable,which may have potential clinical application value in the treatment of lung cancer.

Yunchu Zhang;Tingting Li;Yuzhu Hu;Jing Chen;Yihong He;Xiang Gao;Yan Zhang

Department of Thoracic Oncology,Cancer Center,State Key Laboratory of Biotherapy,West China Hospital,West China Medical School,Sichuan University and Collaborative Innovation Center for Biotherapy,Chengdu 610041,China;Department of Neurosurgery and Institute of Neurosurgery,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University and Collaborative Innovation Center for Biotherapy,Chengdu 610041,China

中国化学快报（英文版）

[1]Yunchu Zhang;Tingting Li;Yuzhu Hu;Jing Chen;Yihong He;Xiang Gao;Yan Zhang-.Co-delivery of doxorubicin and curcumin via cRGD-peptide modified PEG-PLA self-assembly nanomicelles for lung cancer therapy)[J].中国化学快报（英文版）,2022(05):2507-2511

nanomicelle

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