典型文献
Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy
文献摘要：
Photodynamic therapy(PDT)has been widely investigated for cancer therapy.The intracellular accumu-lation of reactive oxygen species(ROS)-damaged protein facilitates tumor cell apoptosis.However,there is growing evidence that the ubiquitin-proteasome pathway(UPP)significantly impedes PDT by prevent-ing the enrichment of ROS-damaged proteins in tumor cells.To tackle this challenge,we report a facile dual-drug nanoassembly based on the discovery of an interesting co-assembly of bortezomib(BTZ,a pro-teasome inhibitor)and pyropheophorbide a(PPa)for proteasome inhibition-mediated PDT sensitization.The precisely engineered nanoassembly with the optimal dose ratio of BTZ and PPa demonstrates mul-tiple advantages,including simple fabrication,high drug co-loading efficiency,flexible dose adjustment,good colloidal stability,long systemic circulation,favorable tumor-specific accumulation,as well as sig-nificant enrichment of ROS-damaged proteins in tumor cells.As a result,the cooperative nanoassembly exhibits potent synergistic antitumor activity in vivo.This study provides a novel dual-drug engineering modality for multimodal cancer treatment.
文献关键词：
中图分类号：
作者姓名：
Fujun Yang;Qingyu Ji;Rui Liao;Shumeng Li;Yuequan Wang;Xuanbo Zhang;Shenwu Zhang;Haotian Zhang;Qiming Kan;Jin Sun;Zhonggui He;Bingjun Sun;Cong Luo
作者机构：
Department of Pharmaceutics,Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China;Department of Pharmacology,School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China
文献出处：
引用格式：
[1]Fujun Yang;Qingyu Ji;Rui Liao;Shumeng Li;Yuequan Wang;Xuanbo Zhang;Shenwu Zhang;Haotian Zhang;Qiming Kan;Jin Sun;Zhonggui He;Bingjun Sun;Cong Luo-.Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy)[J].中国化学快报（英文版）,2022(04):1927-1932
A类：
nanoassembly,teasome,pyropheophorbide,PPa
B类：
Precisely,engineering,dual,drug,cooperative,proteasome,inhibition,potentiated,photodynamic,therapy,Photodynamic,PDT,has,been,widely,investigated,cancer,intracellular,reactive,oxygen,species,ROS,damaged,facilitates,apoptosis,However,there,growing,evidence,that,ubiquitin,pathway,UPP,significantly,impedes,by,prevent,enrichment,proteins,cells,To,tackle,this,challenge,report,facile,discovery,interesting,bortezomib,BTZ,inhibitor,mediated,sensitization,precisely,engineered,optimal,dose,ratio,demonstrates,tiple,advantages,including,simple,fabrication,high,loading,efficiency,flexible,adjustment,good,colloidal,stability,long,systemic,circulation,favorable,specific,accumulation,well,result,exhibits,synergistic,antitumor,activity,vivo,This,study,provides,novel,modality,multimodal,treatment
AB值：
0.565239
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
