Nano-drug delivery systems with multiple stimulus-responsive capabilities have superior response per-formance and efficient drug release.Nevertheless,it is sophisticated to construct multiple stimulus-responsive systems where the two or more functional groups need to be introduced simultaneously.Xanthate,one functional group with pH and H2O2 stimulus responsiveness,has significant potential ap-plications for building dual-responsive drug delivery system.Herein,we present a novel dual stimuli-responsive supramolecular drug delivery system by using sodium xanthate derivative(SXD)as guest molecule and quaternary ammonium capped pillar[5]arene(QAP5)as host molecule through host-guest interaction on the basis of electrostatic interaction.The amphiphile QAP5?SXD could self-assemble into vesicles to efficiently load the anti-cancer drug DOX.The experimental results showed that QAP5?SXD nanoparticles could achieve efficient drug delivery and controlled release in the tumor microenviron-ment.Cytotoxicity experiments proved that DOX@QAP5?SXD nanoparticles could significantly improve the anticancer efficiency of free DOX on cancer cells.The present study provides an efficient strategy to develop supramolecular nanocarriers with dual-responsiveness in one functional group for controlled drug release.

Ziyan Shen;Ning Ma;Feng Wang;Jiaming Ren;Chenxi Hou;Shuang Chao;Yuxin Pei;Zhichao Pei

Shaanxi Key Laboratory of Natural Products&Chemical Biology,College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China

中国化学快报（英文版）

[1]Ziyan Shen;Ning Ma;Feng Wang;Jiaming Ren;Chenxi Hou;Shuang Chao;Yuxin Pei;Zhichao Pei-.pH-and H2O2-sensitive drug delivery system based on sodium xanthate:Dual-responsive supramolecular vesicles from one functional group)[J].中国化学快报（英文版）,2022(10):4563-4566

Xanthate,SXD,QAP5,amphiphile

H2O2,sensitive,drug,delivery,sodium,xanthate,Dual,supramolecular,vesicles,from,one,functional,Nano,systems,multiple,stimulus,capabilities,have,superior,response,formance,release,Nevertheless,sophisticated,construct,where,two,more,groups,need,be,introduced,simultaneously,responsiveness,has,potential,plications,building,dual,Herein,present,novel,stimuli,by,using,derivative,guest,molecule,quaternary,ammonium,capped,pillar,arene,host,through,interaction,basis,electrostatic,could,self,assemble,into,efficiently,load,DOX,experimental,results,showed,nanoparticles,achieve,controlled,tumor,microenviron,Cytotoxicity,experiments,proved,significantly,improve,anticancer,efficiency,free,cells,study,provides,strategy,develop,nanocarriers

0.460595