典型文献
NIR-Ⅱ fluorescence visualization of ultrasound-induced blood-brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles
文献摘要：
Focused ultrasound(FUS)-induced blood-brain barrier(BBB)opening is crucial for enhancing glioblas-toma(GBM)therapies.However,an in vivo imaging approach with a high spatial-temporal resolution to monitor the BBB opening process in situ and synchronously is still lacking.Herein,we report the use of indocyanine green(ICG)-dopped microbubbles(MBs-ICG)for visualizing the FUS-induced BBB opening and enhancing the photothermal therapy(PTT)against GBM.The MBs-ICG show bright fluores-cence in the second near-infrared window(NIR-Ⅱ),ultrasound contrast,and ultrasound-induced size transformation properties.By virtue of complementary contrast properties,MBs-ICG can be successfully applied for cerebral vascular imaging with NIR-Ⅱ fluorescence resolution of～168.9 μm and ultrasound penetration depth of～7 mm.We further demonstrate that MBs-ICG can be combined with FUS for in situ and synchronous visualization of the BBB opening with a NIR-Ⅱ fluorescence signal-to-background ratio of 6.2±1.2.Finally,our data show that the MBs-ICG transform into lipid-ICG nanopar-ticles under FUS irradiation,which then rapidly penetrate the tumor tissues within 10 min and enhance PTT in orthotopic GBM-bearing mice.The multifunctional MBs-ICG approach provides a novel paradigm for monitoring BBB opening and enhancing GBM therapy.
文献关键词：
中图分类号：
作者姓名：
Simin Liang;Dehong Hu;Guofeng Li;Duyang Gao;Fei Li;Hairong Zheng;Min Pan;Zonghai Sheng
作者机构：
Department of Ultrasonography,Shenzhen Hospital(Futian)of Guangzhou University of Chinese Medicine,Shenzhen 518034,China;Paul C Lauterbur Research Center for Biomedical Imaging,CAS Key Laboratory of Health Informatics,Shenzhen Key Laboratory of Ultrasound Imaging and Therapy,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;School of Biomedical Engineering,Guangdong Medical University,Dongguan 523808,China
文献出处：
引用格式：
[1]Simin Liang;Dehong Hu;Guofeng Li;Duyang Gao;Fei Li;Hairong Zheng;Min Pan;Zonghai Sheng-.NIR-Ⅱ fluorescence visualization of ultrasound-induced blood-brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles)[J].科学通报（英文版）,2022(22):2316-2326
A类：
glioblas,dopped
B类：
NIR,fluorescence,visualization,ultrasound,induced,blood,brain,barrier,opening,enhanced,photothermal,therapy,against,glioblastoma,using,indocyanine,green,microbubbles,Focused,FUS,BBB,crucial,enhancing,GBM,therapies,However,vivo,imaging,approach,high,spatial,temporal,resolution,process,situ,synchronously,still,lacking,Herein,report,ICG,MBs,visualizing,PTT,show,bright,second,near,infrared,window,contrast,size,transformation,properties,By,virtue,complementary,can,successfully,applied,cerebral,vascular,penetration,depth,We,further,demonstrate,that,combined,signal,background,Finally,our,data,into,lipid,nanopar,ticles,under,irradiation,which,then,rapidly,penetrate,tumor,tissues,within,orthotopic,bearing,mice,multifunctional,provides,novel,paradigm,monitoring
AB值：
0.475624
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