典型文献
A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy
文献摘要：
It is of great significance to develop effective antibacterial agents and methods to combat drug resistant bacterial infections due to its increasing threaten to human health and the ineffectiveness of antibiotics.Herein,a multifunctional hybrid nano-assembly(M1-Fe NPs)based on conjugated oligomer and ferrous ion was engineered with favorable bactericidal activity for synergetic antibacterial therapy.The chela-tion of ferrous ion not only enhances the photothermal conversion efficiency of M1 but also endows the nano-assembly with catalytic capability of transferring H2O2 into stronger oxidant hydroxyl radicals(·OH).Meanwhile,the generated heat can further promote the Fenton reaction activity.By generating cy-totoxic heat and oxidative·OH,M1-Fe NPs can effectively kill Staphylococcus aureus in vitro and in vivo with the aid of low dosage of H2O2.The work provides a new multifunctional platform for combinational drug resistant antibacterial therapy and even antitumor therapy.
文献关键词：
中图分类号：
作者姓名：
Yunxia Wang;Chuangxin Zhang;Hui Zhang;Liheng Feng;Libing Liu
作者机构：
School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;Department of Nutrition and Health,China Agricultural University,Beijing 100193,China;Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China
文献出处：
引用格式：
[1]Yunxia Wang;Chuangxin Zhang;Hui Zhang;Liheng Feng;Libing Liu-.A hybrid nano-assembly with synergistically promoting photothermal and catalytic radical activity for antibacterial therapy)[J].中国化学快报（英文版）,2022(10):4605-4609
A类：
totoxic
B类：
hybrid,nano,assembly,synergistically,promoting,photothermal,catalytic,activity,antibacterial,therapy,It,great,significance,develop,agents,methods,combat,drug,resistant,infections,due,its,increasing,threaten,human,health,ineffectiveness,antibiotics,Herein,multifunctional,M1,NPs,conjugated,oligomer,ferrous,was,engineered,favorable,bactericidal,synergetic,chela,not,only,enhances,conversion,efficiency,but,also,endows,capability,transferring,H2O2,into,stronger,oxidant,hydroxyl,radicals,Meanwhile,generated,heat,further,promote,Fenton,reaction,By,generating,oxidative,effectively,kill,Staphylococcus,aureus,vitro,vivo,aid,low,dosage,work,provides,new,platform,combinational,even,antitumor
AB值：
0.619739
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