典型文献
Ultrasensitive and accurate diagnosis of urothelial cancer by plasmonic AuNRs-enhanced fluorescence of near-infrared Ag2S quantum dots
文献摘要：
Urothelial carcinoma(UC)is a common malignant tumor in the urinary system with high recurrence rate and low survival rate 5 years after surgery.At present,imaging examination and other diagnostic methods have some shortcomings such as invasiveness and non-speci-ficity.Therefore,it is urgent to develop a simple,rapid,noninvasive,highly sensitive and highly specific strategy to diagnose UC.Herein,a high-performance fluorescence sensor was constructed by the plasmonic gold nanorods(AuNRs)-enhanced near-infrared(NIR)fluorescence of silver sulfide quantum dots(Ag2S QDs).The designed sensor can be used for the fast and accurate detection of small molecule single-transmembrane protein(FXYD3),which is overexpressed in 90％of ureteral cancers and 84％of high-grade bladder cancers.Due to its high specificity,the NIR fluorescence sensor achieves the detection of FXYD3 in the range of 0.25-150 ng-ml-1 with a detection limit of 0.2 ng·ml-1.Importantly,it also can be used for accurate diagnosis of FXYD3 in the urine of patients with relevant cancers,and the results are consistent with clinical cystoscopy and pathological analysis.The proposed fluo-rescence sensor provides a simple,ultrasensitive,reliable method for UC screening,tumor-grade classification and postoperative monitoring and will have great potential for clinical applications.
文献关键词：
中图分类号：
作者姓名：
Dong Zhang;Cai-Ping Ding;Xiao-Yue Zheng;Jia-Zhou Ye;Zi-Hai Chen;Jian-Hua Li;Ze-Jun Yan;Jun-Hui Jiang;You-Ju Huang
作者机构：
Department of Urology&Nephrology,Ningbo First Hospital,The Affiliated Hospital of Zhejiang University,Ningbo 315000,China;College of Material,Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou 311121,China;Anhui Shenghaitang Traditional Chinese Medicine Decoction Pieces Co.,Ltd,Bozhou 236800,China
文献出处：
引用格式：
[1]Dong Zhang;Cai-Ping Ding;Xiao-Yue Zheng;Jia-Zhou Ye;Zi-Hai Chen;Jian-Hua Li;Ze-Jun Yan;Jun-Hui Jiang;You-Ju Huang-.Ultrasensitive and accurate diagnosis of urothelial cancer by plasmonic AuNRs-enhanced fluorescence of near-infrared Ag2S quantum dots)[J].稀有金属（英文版）,2022(11):3828-3838
A类：
FXYD3,cystoscopy
B类：
Ultrasensitive,accurate,diagnosis,urothelial,by,plasmonic,AuNRs,enhanced,fluorescence,near,infrared,Ag2S,quantum,dots,Urothelial,carcinoma,UC,common,malignant,tumor,urinary,system,recurrence,low,survival,years,after,surgery,At,present,imaging,examination,other,diagnostic,methods,have,some,shortcomings,such,invasiveness,Therefore,urgent,develop,simple,rapid,noninvasive,highly,strategy,diagnose,Herein,performance,sensor,was,constructed,gold,nanorods,NIR,silver,sulfide,QDs,designed,be,used,fast,detection,small,molecule,single,transmembrane,protein,which,overexpressed,ureteral,cancers,grade,bladder,Due,its,specificity,achieves,range,ml,limit,Importantly,also,urine,patients,relevant,results,consistent,clinical,pathological,analysis,proposed,provides,ultrasensitive,reliable,screening,classification,postoperative,monitoring,will,great,potential,applications
AB值：
0.556562
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