Phototheranostic with highly integrated functions is an attractive platform for cancer management.It re-mains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity.Herein,the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ)fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size,stable dispersibility,NIR-Ⅱ fluorescence emission,photothermal conversion,and biocompatibility.Benefiting from the complemen-tary PA/NIR-Ⅱ fluorescence bimodal imaging,this nanoplatform was successfully applied in precise vas-culature delineation and tumor diagnosis.Interestingly,the tumor was clearly detected by NIR-Ⅱ fluores-cence imaging with the highest tumor-to-normal-tissue ratio up to 12.69,while signal interference from the liver was significantly reduced,due to the difference in the elimination rate of the nanoplatform in the liver and tumor.Under the precise guidance of the image,the tumor was accurately resected,and the simulated residual lesion after surgery was completely ablated by adjuvant PTT.This combined ther-apy showed improved antitumor efficacy over the individual surgery or PTT.This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation.

Xiuping Han;Wenyou Fang;Tianqi Zhang;Xuan Zhong;Kun Qian;Zhitao Jiang;Rongfeng Hu;Guoqiang Shao;Lei Zhang;Qing Zhang

Department of Pharmaceutics and Key Laboratory of Cardiovascular&Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;Department of Nuclear Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 211166,China;Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Anhui Province Engineering Technology Research Center of Modern Pharmaceutical Preparation,Anhui University of Chinese Medicine,Hefei 230012,China;Department of Nuclear Medicine,Taizhou People's Hospital,Nanjing University of Chinese Medicine,Taizhou 225300,China;Center for Molecular Imaging Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China;State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM),Nanjing University of Posts&Telecommunications,Nanjing 210023,China

材料科学技术（英文版）

[1]Xiuping Han;Wenyou Fang;Tianqi Zhang;Xuan Zhong;Kun Qian;Zhitao Jiang;Rongfeng Hu;Guoqiang Shao;Lei Zhang;Qing Zhang-.A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efficacy)[J].材料科学技术（英文版）,2022(35):208-218

phototheranostic,Phototheranostic,culature

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