Precise and early detection of β-amyloid(Aβ)deposits in situ and in real time is pivotal to the diagnosis and early intervention of Alzheimer's disease(AD).Optical imaging stands out to be a promising technique for such a task;however,it still remains a big challenge,due to the lack of high-performance imaging contrast agent.Restricted by poor blood-brain barrier(BBB)penetr-ability,short-wavelength excitation and emission,as well as the aggregation-caused quenching effect,the widely used gold-standard probes cannot be used for early in-vivo imaging of Aβ deposits.Herein,we integrate the Aβ deposits-favored geometry,amphiphilic and zwitterionic molecular structure,extended D-πt-A electronic structure,and 3D conformation into one molecule,facilely establishing a simple and economic imaging contrast agent that enjoys high specificity and affinity to Aβ deposits,good BBB penetrability,bright red/near-infrared fluorescence,low interference from autofluorescence,aggregation-induced emission(AIE)feature,high signal-to-noise ratio(SNR),and high contrast.In-vitro,ex-vivo,and in-vivo experiments with different strains of mice indicate that AIE-CNPy-AD holds the universality to Aβ deposits identification.Noteworthily,AIE-CNPy-AD is even able to precisely trace the small and sparsely-distributed Aβ deposits in AD model mice as young as 4-month-old APP/PS1 mice,the youngest having Aβ deposits.Moreover,the present probe could clearly reveal the increase and enlargement of Aβ deposits as the mice grow.Therefore,AIE-CNPy-AD might be an ideal alternative for early AD diagnosis and highly reliable monitoring of AD progression.

Yipu Wang;Dong Mei;Xinyi Zhang;Da-Hui Qu;Ju Mei

Key Laboratory for Advanced Materials,Feringa Nobel Prize Scientist Joint Research Center Frontiers Science Center for Materiobiology and Dynamic Chemistry,Joint International Research Laboratory for Precision Chemistry and Molecular Engineering,Institute of Fine Chemicals,School of Chemistry&Molecular Engineering,East China University of Science&Technology,Shanghai 200237,China;Clinical Research Center,Beijing Children's Hospital,Capital Medical University,National Center for Children s Health,Beijing 100045,China

中国科学:化学（英文版）

[1]Yipu Wang;Dong Mei;Xinyi Zhang;Da-Hui Qu;Ju Mei-.Visualizing Aβ deposits in live young AD model mice with a simple red/near-infrared-fluorescent AIEgen)[J].中国科学:化学（英文版）,2022(02):339-352

penetr,CNPy

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