Light-responsive carriers have been used for the controlled release of antitumor drugs in recent years.However,most light-responsive vectors require high-energy ultraviolet or visible light to achieve local drug release,and ultraviolet light would cause cellular damage.Near-infrared light has a deeper tissue-penetration depths and minimal harm to tissues,but it is difficult to cleave the chemical bond directly.The aim of this study is to develop a novel near-infrared light-responsive carrier for local release of anti-tumor drugs.Unsaturated phospholipids can be oxidized by singlet oxygen to achieve liposomal drug re-lease,and singlet oxygen can be produced by photosensitizer under light irradiation.A new near-infrared light-responsive nanoliposome was designed that imparts light-triggered local drug release.Nanolipo-somes,which were composed of matrix phospholipids and unsaturated phospholipids,were prepared by ammonium sulfate gradient method,and loaded with antitumor drug doxorubicin(DOX)and photosensi-tizer 1,4,8,11,15,18,22,25-octabutoxypalladium phthalocyanine.Under near-infrared light,photosensitizers could produce singlet oxygen and damage tumor cells by photodynamic therapy.Simultaneously,the un-saturated phospholipids were oxidized by singlet oxygen and result in DOX release,causing sustained cell damage by chemotherapy.Near-infrared light-responsive nanoliposomes exhibit enhanced anticancer ac-tivity owing to combined treatment of photodynamic therapy and chemotherapy.A new platform is thus offered for designing effective intracellular drug-release systems,holding great promise for future cancer therapy.

Guangzhao Lu;Xiqing Gao;He Zhang;Yeye Zhang;Yuan Yu;Zhiguo Sun;Wei Li;Wei Wu;Ying Lu;Hao Zou

Department of Pharmaceutical Sciences,School of Pharmacy,Naval Medical University,Shanghai 200433,China;Department of Pharmacy,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Laboratory of Nano Biomedicine&International Joint Cancer Institute,Naval Medical University,Shanghai 200433,China;Key Laboratory of Smart Drug Delivery of MOE,School of Pharmacy,Fudan University,Shanghai 200032,China

中国化学快报（英文版）

[1]Guangzhao Lu;Xiqing Gao;He Zhang;Yeye Zhang;Yuan Yu;Zhiguo Sun;Wei Li;Wei Wu;Ying Lu;Hao Zou-.Near-infrared light(NIR)-responsive nanoliposomes combining photodynamic therapy and chemotherapy for breast tumor control)[J].中国化学快报（英文版）,2022(04):1923-1926

nanoliposomes,Unsaturated,nanoliposome,Nanolipo,photosensi,tizer,octabutoxypalladium

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