The near-infrared (NIR) persistent luminescence materials (PLMs) can remain long-lasting luminescence after removal of the excitation light, which permits bioimaging with high sensitivity owing to the absence of background fluorescence interference from in situ excitation. Recently, the NIR PLMs have aroused intensive research interest in bioimaging. However, the optimal excitation wavelength of current NIR PLMs is located in the ultraviolet region with shallow tissue penetration, making it difficult to activate effectively in vivo, and seriously hindering their further application in bioimaging. Herein, we report a novel kind of Cr3+ ions and Y3+ ions co-doped NIR PLM, Zn1.3Ga1.4Sn0.3O4:Cr3+,Y3+ (ZGSCY), which emits NIR persistent luminescence at 696 nm. Compared with Zn1.3Ga1.4Sn0.3O4:Cr3+ (ZGSC) excited by the light with a wavelength in the biological window (>650 nm), after being co-doped with Y3+ions, the NIR persistent luminescence performance of ZGSCY is significantly improved because of the increase of trap concentration in the matrix. In addition, we synthesized ZGSCY nanoparticles (NPs) by the combustion method, which exhibit excellent optical properties after being excited by the light with a wavelength in the biological window. After surface modification with PEG, the ZGSCY NPs present low cytotoxicity. Notably, due to the co-doping of Y3+ ions, the signal-to-noise ratio (SNR) of ZGSCY NPs in vivo imaging is about 1.8 times higher than that of the ZGSC NPs. Furthermore, the rechargeable in vivo imaging and passive tumor-targeted imaging are successfully achieved by activating with a light-emitting diode (LED, 659 nm) after intravenous injection of ZGSCY. Thus, this kind of NIR PLM with high excitation efficiency performance in the biological window is expected to promote its biomedical application in deep tissues.

Huimin Jiang;Lin Liu;Kexin Yu;Xianggui Yin;Shenghui Zheng;Liang Song;Junpeng Shi;Yun Zhang

College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350007,China;Key Laboratory of Design and Assembly of Functional Nanostructures,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fuzhou 350002,China;Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials,Xiamen Institute of Rare Earth Materials,Haixi Institute,Chinese Academy of Sciences,Xiamen 361021,China;Institute of Urban Environment,Chinese Academy of Sciences,Xiamen 361021,China;Ganjiang Innovation Academy,Chinese Academy of Sciences,Ganzhou 341000,China

稀土学报（英文版）

[1]Huimin Jiang;Lin Liu;Kexin Yu;Xianggui Yin;Shenghui Zheng;Liang Song;Junpeng Shi;Yun Zhang-.Cr3+/Y3+co-doped persistent luminescence nanoparticles with biological window activation for in vivo repeatable imaging)[J].稀土学报（英文版）,2022(09):1389-1398

Y3+co,PLMs,3Ga1,4Sn0,ZGSCY,ZGSC,Y3+ions

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