典型文献
Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers
文献摘要：
Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phos-phate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treat-ment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overex-pressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanopar-ticles have promising applications in treating tumor disease.
文献关键词：
中图分类号：
作者姓名：
Baolong Niu;Min Li;Jianhong Jia;Lixuan Ren;Xin Gang;Bin Nie;Yanying Fan;Xiaojie Lian;Wenfeng Li
作者机构：
College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Key Laboratory of Interface Science and Engineering in Advanced Materials,Taiyuan University of Technology,Taiyuan 030024,China;School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030001,China;Department of Biomedical Engineering,Research Center for Nano-biomaterials&Regenerative Medicine,College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Shanxi Key Laboratory of Material Strength&Structural Impact,Institute of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China
文献出处：
引用格式：
[1]Baolong Niu;Min Li;Jianhong Jia;Lixuan Ren;Xin Gang;Bin Nie;Yanying Fan;Xiaojie Lian;Wenfeng Li-.Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers)[J].中国化学工程学报（英文版）,2022(08):244-252
A类：
FCNs,overex
B类：
Preparation,study,sensitive,amorphous,calcium,phosphate,nanocarriers,Recently,multifunctional,nanoparticles,have,shown,great,prospects,cancer,treatment,which,simultaneously,drug,image,tumor,cells,In,this,paper,we,designed,luminescent,platform,hydrothermal,hyaluronic,acid,HA,ACP,properties,delivery,targeting,shows,load,curcumin,Cur,responsive,release,behavior,excellent,biocompatibility,dispersed,cytoplasm,through,pressed,CD44,receptor,that,actively,targeted,into,human,lung,A549,Meanwhile,viability,was,significantly,inhibited,vitro,prepared,both,exhibit,bioimaging,performance,Hence,promising,applications,treating,disease
AB值：
0.531265
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
