典型文献
Photoacoustic detection of follicular thyroid carcinoma using targeted Nano-Au-Tripods
文献摘要：
Follicular thyroid carcinoma(FTC)is the second most common form of thyroid malignancy,and it is asso-ciated with more aggressive growth and worse long-term survival outcomes relative to papillary thyroid carcinoma(PTC).Reliable approaches to preoperative FTC detection,however,remain to be established.Herein,a targeted Affibody-Au-Tripod nanoprobe was developed and successfully utilized to facilitate the targeted photoacoustic imaging(PAI)of epidermal growth factor receptor(EGFR)-positive cells and tumors.These Affibody-Au-Tripods were found to be highly sensitive and specific for cells expressing EGFR when used as a PA contrast agent in vitro,and studies conducted in an FTC-133 subcutaneous tumor model system in mice further revealed that these Affibody-Au-Tripods were able to specifically target these EGFR-expressing tumors while providing a strong photoacoustic signal in vivo.Importantly,these nanoprobes exhibited negligible cytotoxicity and robust chemical and physical stability,making Affibody-Au-Tripods promising candidates for targeted PAI-based FTC diagnosis.In addition,these nanoprobes have the potential to facilitate the individualized treatment of patients harboring EGFR-positive tumors.
文献关键词：
中图分类号：
作者姓名：
Yang Gui;Kai Cheng;Ruojiao Wang;Sirui Liu;Chenyang Zhao;Rui Zhang;Ming Wang;Zhen Cheng;Meng Yang
作者机构：
Department of Ultrasound,State Key Laboratory of Complex Severe and Rare Diseases,Pecking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Molecular Imaging Program at Stanford(MIPS),Department of Radiology and Bio-X Program,School of Medicine,Stanford University,Stanford CA 94305-5484,USA
文献出处：
引用格式：
[1]Yang Gui;Kai Cheng;Ruojiao Wang;Sirui Liu;Chenyang Zhao;Rui Zhang;Ming Wang;Zhen Cheng;Meng Yang-.Photoacoustic detection of follicular thyroid carcinoma using targeted Nano-Au-Tripods)[J].中国化学工程学报（英文版）,2022(04):1-7
A类：
Tripods
B类：
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AB值：
0.571424
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