典型文献
Non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine
文献摘要：
As an emerging cancer therapeutic target,non-apoptotic cell death such as ferroptosis,ne-croptosis and pyroptosis,etc.,has revealed significant potential in cancer treatment for bypassing apoptosis to enhance the undermined therapeutic efficacy triggered by apoptosis resistance.A variety of anticancer drugs,synthesized compounds and natural products have been proven recently to induce non-apoptotic cell death and exhibit excellent anti-tumor effects.Moreover,the convergence of nanotech-nology with functional materials and biomedicine science has provided tremendous opportunities to construct non-apoptotic cell death-based nanomedicine for innovative cancer therapy.Nanocarriers are not only employed in targeted delivery of non-apoptotic inducers,but also used as therapeutic compo-nents to induce non-apoptotic cell death to achieve efficient tumor treatment.This review first introduces the main characteristics,the mechanism and various pharmacological modulators of different non-apoptotic cell death forms,including ferroptosis,necroptosis,pyroptosis,autophagy,paraptosis,lysosomal-dependent cell death,and oncosis.Second,we comprehensively review the latest progresses of nanomedicine that induces various forms of non-apoptotic cell death and focus on the nanomedicine targeting different pathways and components.Furthermore,the combination therapies of non-apoptotic cell death with photothermal therapy,photodynamic therapy,immunotherapy and other modalities are summarized.Finally,the challenges and future perspectives in this regard are also discussed.
文献关键词：
中图分类号：
作者姓名：
Xuan Wang;Peng Hua;Chengwei He;Meiwan Chen
作者机构：
State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,SAR 999078,China
文献出处：
引用格式：
[1]Xuan Wang;Peng Hua;Chengwei He;Meiwan Chen-.Non-apoptotic cell death-based cancer therapy:Molecular mechanism,pharmacological modulators,and nanomedicine)[J].药学学报（英文版）,2022(09):3567-3593
A类：
croptosis,Nanocarriers,paraptosis,oncosis
B类：
Non,apoptotic,death,Molecular,mechanism,pharmacological,modulators,nanomedicine,emerging,therapeutic,such,ferroptosis,pyroptosis,etc,has,revealed,significant,potential,treatment,bypassing,apoptosis,enhance,undermined,efficacy,triggered,resistance,variety,anticancer,drugs,synthesized,compounds,natural,products,have,been,proven,recently,exhibit,excellent,tumor,effects,Moreover,convergence,nanotech,nology,functional,materials,biomedicine,science,provided,tremendous,opportunities,construct,innovative,are,only,employed,targeted,delivery,inducers,but,also,used,achieve,efficient,This,review,first,introduces,main,characteristics,various,different,forms,including,necroptosis,autophagy,lysosomal,dependent,Second,we,comprehensively,latest,progresses,that,induces,focus,targeting,pathways,components,Furthermore,combination,therapies,photothermal,photodynamic,immunotherapy,modalities,summarized,Finally,challenges,future,perspectives,this,regard,discussed
AB值：
0.529884
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