典型文献
Dual-targeting prodrug nanotheranostics for NIR-Ⅱ fluorescence imaging-guided photo-immunotherapy of glioblastoma
文献摘要：
Glioblastoma(GBM)therapy is severely impaired by the blood-brain barrier(BBB)and invasive tumor growth in the central nervous system.To improve GBM therapy,we herein presented a dual-targeting nanotheranostic for second near-infrared(NIR-Ⅱ)fluorescence imaging-guided photo-immunotherapy.Firstly,a NIR-Ⅱ fluorophore MRP bearing donor-acceptor-donor(D-A-D)backbone was synthesized.Then,the prodrug nanotheranostics were prepared by self-assembling MRP with a pro-drug of JQ1(JPC)and T7 ligand-modified PEG5k-DSPE.T7 can cross the BBB for tumor-targeted de-livery of JPC and MRP.JQ1 could be restored from JPC at the tumor site for suppressing interferon gamma-inducible programmed death ligand 1 expression in the tumor cells.MRP could generate NIR-Ⅱ fluorescence to navigate 808 nm laser,induce a photothermal effect to trigger in-situ antigen release at the tumor site,and ultimately elicit antitumor immunogenicity.Photo-immunotherapy with JPC and MRP dual-loaded nanoparticles remarkably inhibited GBM tumor growth in vivo.The dual-targeting na-notheranostic might represent a novel nanoplatform for precise photo-immunotherapy of GBM.
文献关键词：
中图分类号：
作者姓名：
Fenglin Li;Yi Lai;Jiayi Ye;Madiha Saeed;Yijing Dang;Zhifeng Zou;Fangmin Chen;Wen Zhang;Zhiai Xu
作者机构：
School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,China;State Key Laboratory of Drug Research&Center of Pharmaceutics,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China
文献出处：
引用格式：
[1]Fenglin Li;Yi Lai;Jiayi Ye;Madiha Saeed;Yijing Dang;Zhifeng Zou;Fangmin Chen;Wen Zhang;Zhiai Xu-.Dual-targeting prodrug nanotheranostics for NIR-Ⅱ fluorescence imaging-guided photo-immunotherapy of glioblastoma)[J].药学学报（英文版）,2022(09):3486-3497
A类：
PEG5k,notheranostic
B类：
Dual,targeting,prodrug,nanotheranostics,NIR,fluorescence,imaging,guided,immunotherapy,glioblastoma,Glioblastoma,GBM,severely,impaired,by,blood,brain,barrier,BBB,invasive,growth,central,nervous,system,To,improve,herein,presented,dual,second,near,infrared,Firstly,fluorophore,MRP,bearing,donor,acceptor,backbone,was,synthesized,Then,were,prepared,self,assembling,JQ1,JPC,T7,ligand,modified,DSPE,can,cross,targeted,livery,could,restored,from,site,suppressing,interferon,gamma,inducible,programmed,death,expression,cells,generate,navigate,laser,induce,photothermal,effect,trigger,situ,antigen,release,ultimately,elicit,antitumor,immunogenicity,Photo,loaded,nanoparticles,remarkably,inhibited,vivo,might,represent,novel,nanoplatform,precise
AB值：
0.56237
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