典型文献
A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer
文献摘要：
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy.However,despite great promise for a variety of cancers,the efficacy of immune check-point inhibitors is still low in colorectal cancer(CRC).This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME).Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD),demonstrating great potential for remodeling the immuno-suppressive TME.In this study,the potential of ginsenoside Rg3(Rg3)as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches.The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN)that elicited reactive oxygen species(ROS).To ameliorate in vivo delivery barriers associated with chemotherapeutic drugs,a folate(FA)-targeted polyethylene gly-col(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP)was developed for co-encapsulation of Rg3 and QTN.The resultant nanoformulation(CD-PEG-FA.Rg3.QTN)significantly prolonged blood cir-culation and enhanced tumor targeting in an orthotopic CRC mouse model,resulting in the conversion of immunosuppressive TME.Furthermore,the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1.The study provides a promising strategy for the treatment of CRC.
文献关键词：
中图分类号：
作者姓名：
Dandan Sun;Yifang Zou;Liu Song;Shulan Han;Hao Yang;Di Chu;Yun Dai;Jie Ma;Caitriona M.O'Driscoll;Zhuo Yu;Jianfeng Guo
作者机构：
School of Pharmaceutical Sciences,Jilin University,Changchun 130021,China;Laboratory of Cancer Precision Medicine,The First Hospital of Jilin University,Changchun 130021,China;Pharmacodelivery Group,School of Pharmacy,University College Cork,Cork T12 YT20,Ireland;Department of Hepatopathy,Shuguang Hospital,Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China
文献出处：
引用格式：
[1]Dandan Sun;Yifang Zou;Liu Song;Shulan Han;Hao Yang;Di Chu;Yun Dai;Jie Ma;Caitriona M.O'Driscoll;Zhuo Yu;Jianfeng Guo-.A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer)[J].药学学报（英文版）,2022(01):378-393
A类：
nanoformulation
B类：
cyclodextrin,achieves,delivery,ginsenoside,Rg3,quercetin,immunotherapy,colorectal,immune,checkpoint,blockade,has,profoundly,revolutionized,field,However,despite,great,promise,variety,cancers,efficacy,inhibitors,still,low,CRC,This,mainly,due,immunosuppressive,feature,tumor,microenvironment,TME,Emerging,evidence,reveals,that,certain,chemotherapeutic,drugs,immunogenic,death,ICD,demonstrating,potential,remodeling,In,this,study,inducer,against,cells,was,confirmed,using,vitro,vivo,experimental,approaches,could,be,significantly,enhanced,by,QTN,elicited,reactive,oxygen,species,ROS,To,ameliorate,barriers,associated,folate,FA,targeted,polyethylene,gly,PEG,modified,amphiphilic,nanoparticle,NP,developed,encapsulation,resultant,prolonged,blood,cir,culation,targeting,orthotopic,mouse,resulting,conversion,Furthermore,achieved,longer,survival,animals,combination,Anti,L1,provides,promising,strategy,treatment
AB值：
0.557706
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