典型文献
Construction and verification of an infectious cDNA clone of coxsackievirus B5
文献摘要：
Dear Editor,
Enteroviruses belonging to the family Picornaviridae are non-enveloped RNA viruses that cause hand-foot-mouth disease(HFMD),which can lead to severe neurological complications.Enteroviruses ge-nomes represent a single open reading frame flanked by 5'-and 3'-un-translated terminal regions(UTRs),constituting the basis for classifying enteroviruses into groups A-D(Zaoutis et al.,1998).Current research is primarily focused on highly prevalent pathogens,including enterovirus A71(EV-A71)and coxsackievirus A16(CV-A16)of group A(Duan et al.,2021).However,group B viruses are also responsible for a significant number of infections that often cause histopathological changes in the heart,brain,and pancreas.For instance,coxsackievirus B5(CV-B5)can induce aseptic meningitis,viral meningitis,acute flaccid paralysis,pancreatitis,and type I diabetes mellitus(Chen et al.,2020;Fran?ozo et al.,2019;Hy?ty et al.,2018).HFMD outbreaks caused by CV-B5 have been reported in China,Southeast Asia,and Europe.However,despite its clinical significance,little is known about its pathogenesis,and in-depth studies on the underlying mechanisms are urgently needed(Gao et al.,2018;Sciandra et al.,2020).
文献关键词：
中图分类号：
作者姓名：
Lifang Song;Bopei Cui;Jinghuan Yang;Xiaotian Hao;Xujia Yan;Jialu Zhang;Dong Liu;Ziyang Song;Qian Wang;Qunying Mao;Zhenglun Liang
作者机构：
National Institute for Food and Drug Control,Beijing 102629,China;Wuhan Institute of Biological Products CO.,LTD,Wuhan 430070,China
文献出处：
引用格式：
[1]Lifang Song;Bopei Cui;Jinghuan Yang;Xiaotian Hao;Xujia Yan;Jialu Zhang;Dong Liu;Ziyang Song;Qian Wang;Qunying Mao;Zhenglun Liang-.Construction and verification of an infectious cDNA clone of coxsackievirus B5)[J].中国病毒学,2022(03):469-471
A类：
Enteroviruses,Enteroviruses,UTRs,enteroviruses,Zaoutis,ozo,Sciandra
B类：
Construction,verification,infectious,cDNA,clone,coxsackievirus,B5,Dear,Editor,belonging,family,Picornaviridae,are,enveloped,that,hand,foot,mouth,disease,HFMD,which,lead,severe,neurological,complications,nomes,represent,single,open,reading,frame,flanked,by,translated,terminal,regions,constituting,basis,classifying,into,groups,Current,research,primarily,focused,highly,prevalent,pathogens,including,A71,EV,A16,CV,Duan,However,also,responsible,significant,number,infections,often,histopathological,changes,heart,brain,pancreas,For,instance,induce,aseptic,meningitis,viral,acute,flaccid,paralysis,pancreatitis,type,diabetes,mellitus,Chen,Fran,Hy,outbreaks,caused,have,been,reported,China,Southeast,Asia,Europe,despite,its,clinical,significance,little,known,about,pathogenesis,depth,studies,underlying,mechanisms,urgently,needed,Gao
AB值：
0.615505
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