典型文献
Interactions between gut microbiota and berberine,a necessary procedure to understand the mechanisms of berberine
文献摘要：
Berberine(BBR),an isoquinoline alkaloid,has been found in many plants,such as Coptis chinensis Franch and Phellodendron chinense Schneid.Although BBR has a wide spectrum of pharmacological effects,its oral bioavailability is extremely low.In recent years,gut microbiota has emerged as a cynosure to un-derstand the mechanisms of action of herbal compounds.Numerous studies have demonstrated that due to its low bioavailability,BBR can interact with the gut microbiota,thereby exhibiting altered pharma-cological effects.However,no systematic and comprehensive review has summarized these interactions and their corresponding influences on pharmacological effects.Here,we describe the direct interactive relationships between BBR and gut microbiota,including regulation of gut microbiota composition and metabolism by BBR and metabolization of BBR by gut microbiota.In addition,the complex interactions between gut microbiota and BBR as well as the side effects and personalized use of BBR are discussed.Furthermore,we provide our viewpoint on future research directions regarding BBR and gut microbiota.This review not only helps to explain the mechanisms underlying BBR activity but also provides support for the rational use of BBR in clinical practice.
文献关键词：
中图分类号：
作者姓名：
Hao Cheng;Juan Liu;Yuzhu Tan;Wuwen Feng;Cheng Peng
作者机构：
State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China
文献出处：
引用格式：
[1]Hao Cheng;Juan Liu;Yuzhu Tan;Wuwen Feng;Cheng Peng-.Interactions between gut microbiota and berberine,a necessary procedure to understand the mechanisms of berberine)[J].药物分析学报（英文）,2022(04):541-555
A类：
cynosure,metabolization
B类：
Interactions,between,gut,microbiota,berberine,necessary,procedure,understand,mechanisms,Berberine,BBR,isoquinoline,alkaloid,has,been,found,many,plants,such,Coptis,chinensis,Franch,Phellodendron,chinense,Schneid,Although,wide,spectrum,pharmacological,effects,its,oral,bioavailability,extremely,low,recent,years,emerged,herbal,compounds,Numerous,studies,have,demonstrated,that,due,can,thereby,exhibiting,altered,However,systematic,comprehensive,review,summarized,these,interactions,their,corresponding,influences,Here,describe,interactive,relationships,including,regulation,composition,metabolism,addition,complex,well,side,personalized,use,are,discussed,Furthermore,our,viewpoint,future,research,directions,regarding,This,not,only,helps,explain,underlying,activity,but,also,provides,support,rational,clinical,practice
AB值：
0.538134
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