典型文献
Amplifying natural antitumor immunity for personalized immunotherapy
文献摘要：
T-cells engineered with T-cell receptors(TCR-T),chimeric antigen receptor(CAR)T-cells,and neoantigen vaccines have each demonstrated therapeutic success in clinical trials,but many of these therapies can only benefit a small group of patient types owing to the restriction of certain tumor-associated antigens;personalized immunotherapy customizes cancer treatments to each patient,achieving greater responses without damaging normal tissues.In a recent Cell Research paper,He et al.show that TCR-T cells engineered with TCRs from naturally occurring tumor antigen-specific(Tas)T-cells are an effective therapy against non-small cell lung carcinoma,and a promising agent for future immunotherapies.
文献关键词：
中图分类号：
作者姓名：
Laura K.Donovan;Michael D.Taylor
作者机构：
Great Ormond Street Institute of Child Health,University College London,London,UK;The Arthur and Sonia Labatt Brain Tumor Research Centre,The Hospital for Sick Children,Toronto,ON,Canada
文献出处：
引用格式：
[1]Laura K.Donovan;Michael D.Taylor-.Amplifying natural antitumor immunity for personalized immunotherapy)[J].细胞研究（英文版）,2022(06):505-506
A类：
Amplifying,customizes,TCRs
B类：
antitumor,immunity,personalized,immunotherapy,cells,engineered,receptors,chimeric,CAR,neoantigen,vaccines,have,each,demonstrated,therapeutic,success,clinical,trials,but,many,these,only,benefit,small,group,patient,types,owing,restriction,certain,associated,antigens,cancer,treatments,achieving,greater,responses,without,damaging,normal,tissues,In,recent,Cell,Research,paper,He,et,show,that,from,naturally,occurring,specific,Tas,are,effective,against,lung,carcinoma,promising,agent,future,immunotherapies
AB值：
0.65319
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