典型文献
Low-dose chloroquine treatment extends the lifespan of aged rats
文献摘要：
Dear Editor,
Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020).However,the safety and efficacy of its applications are still under extensive debate(Solomon and Lee,2009).Here,we dis-covered that low-dose CQ has a geroprotective effect on physiologically aged rats.Low-dose CQ prolonged lifespan,repressed systemic inflammation,and inhibited fibrosis across multiple tissue types in aged rats.Furthermore,we constructed transcriptomic maps for 6 tissues(kidney,small intestine,liver,heart,lung,and aorta)upon CQ treatment,thus revealing the effects of CQ at a systemic level.CQ treatment mitigated age-related molecular changes and repressed genes linked to fibrosis and the inflammatory response.Altogether,our data provide a valuable resource for investigating the impact of CQ on multiple aged tissues,which may facilitate the development of clinical applications that mitigate age-related changes in the elderly.
文献关键词：
中图分类号：
作者姓名：
Wei Li;Zhiran Zou;Yusheng Cai;Kuan Yang;Si Wang;Zunpeng Liu;Lingling Geng;Qun Chu;Zhejun Ji;Piu Chan;Guang-Hui Liu;Moshi Song;Jing Qu;Weiqi Zhang
作者机构：
Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Aging Translational Medicine Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;China National Center for Bioinformation,Beijing 100101,China;Sino-Danish College,University of Chinese Academy of Sciences,Beijing 101408,China;Sino-Danish Center for Education and Research,Beijing 101408,China;Chongqing Renji Hospital,University of Chinese Academy of Sciences,Chongqing 400062,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China
文献出处：
引用格式：
[1]Wei Li;Zhiran Zou;Yusheng Cai;Kuan Yang;Si Wang;Zunpeng Liu;Lingling Geng;Qun Chu;Zhejun Ji;Piu Chan;Guang-Hui Liu;Moshi Song;Jing Qu;Weiqi Zhang-.Low-dose chloroquine treatment extends the lifespan of aged rats)[J].蛋白质与细胞,2022(06):454-461
A类：
Chloroquine,Wellems,Plowe,geroprotective
B类：
Low,dose,chloroquine,treatment,extends,lifespan,aged,rats,Dear,Editor,CQ,has,been,used,anti,malarial,agent,Recently,also,applied,viral,infection,related,diseases,Huang,However,safety,efficacy,its,applications,are,still,under,extensive,debate,Solomon,Lee,Here,covered,that,physiologically,prolonged,repressed,systemic,inflammation,inhibited,fibrosis,across,multiple,types,Furthermore,constructed,transcriptomic,maps,tissues,kidney,small,intestine,liver,heart,lung,aorta,upon,thus,revealing,effects,level,mitigated,molecular,changes,genes,linked,inflammatory,response,Altogether,data,provide,valuable,resource,investigating,impact,which,may,facilitate,development,clinical,elderly
AB值：
0.550976
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
