典型文献
Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies
文献摘要：
Dear Editor,
Foot-and-mouth disease(FMD)is an economically devas-tating and highly contagious viral disease of cloven-hoofed animals with a global distribution.The causative agent,FMD virus(FMDV)is a small non-enveloped RNA virus,belonging to the Aphthoviruses genus within Picornaviridae family(Tuthill et al.,2010).Control of FMD has been largely reliant on vaccinations with inactivated virus vaccines.However,significant antigenic diversity within FMDV serotypes and inability of the vaccines to induce immune protection for a long duration of time impinge on the efficacy of available vaccines.The roles of neutralizing antibodies(NAbs)as the principal protective components of the immune responses to FMDV vaccination or infection have been well established(Pay and Hingley,1987;Juleff et al.,2009).Passive immu-nization of NAbs has also been demonstrated to be effective in curing FMD and many viral diseases(Harmsen et al.,2007;Qiu et al.,2018).A deep understanding of the molecular basis for viral neutralization by antibodies and the identification of key viral epitopes would aid in the develop-ment of potent rationally designed broad-spectrum vaccine.
文献关键词：
中图分类号：
作者姓名：
Hu Dong;Pan Liu;Manyuan Bai;Kang Wang;Rui Feng;Dandan Zhu;Yao Sun;Suyu Mu;Haozhou Li;Michiel Harmsen;Shiqi Sun;Xiangxi Wang;Huichen Guo
作者机构：
State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China;CAS Key Laboratory of Infection and Immunity,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Division Virology,Wageningen Bioveterinary Research,P.O.Box 65,8200 AB Lelystad,The Netherlands
文献出处：
引用格式：
[1]Hu Dong;Pan Liu;Manyuan Bai;Kang Wang;Rui Feng;Dandan Zhu;Yao Sun;Suyu Mu;Haozhou Li;Michiel Harmsen;Shiqi Sun;Xiangxi Wang;Huichen Guo-.Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies)[J].蛋白质与细胞,2022(06):446-453
A类：
Foot,devas,tating,cloven,hoofed,Aphthoviruses,Tuthill,impinge,Hingley,Juleff,Harmsen
B类：
Structural,molecular,basis,foot,mouth,neutralization,by,two,potent,protective,antibodies,Dear,Editor,economically,highly,contagious,viral,animals,global,distribution,causative,agent,FMDV,small,enveloped,belonging,genus,within,Picornaviridae,family,et,Control,has,been,largely,reliant,vaccinations,inactivated,vaccines,However,significant,antigenic,diversity,serotypes,inability,induce,immune,protection,duration,efficacy,available,roles,neutralizing,NAbs,principal,components,responses,infection,have,well,established,Pay,Passive,nization,also,demonstrated,effective,curing,many,diseases,Qiu,deep,understanding,identification,key,epitopes,would,aid,develop,ment,rationally,designed,broad,spectrum
AB值：
0.505616
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