Dear Editor, Stem cell therapy holds enormous and revolutionary promise to treat various age-related diseases,such as diabetes,heart failure,and Parkinson's disease.However,low retention and survival rate of delivered stem cells,partially due to immuno-logical rejection,constitute major hurdles for the clinical implementation of stem cell therapy(Lei et al.,2021a).Since mounting evidence showed that several types of stem cells mainly exert their therapeutic effects through the secretion of paracrine effects,exosomes,which are released by stem cells and execute most paracrine functions,have begun to draw attention in the field(Tran and Damaser,2015).

Jinghui Lei;Xiaoyu Jiang;Wei Li;Jie Ren;Datao Wang;Zhejun Ji;Zeming Wu;Fang Cheng;Yusheng Cai;Zheng-Rong Yu;Juan Carlos Izpisua Belmonte;Chunyi Li;Guang-Hui Liu;Weiqi Zhang;Jing Qu;Si Wang

Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Aging Translational Medicine Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;China National Center for Bioinformation,Beijing 100101,China;Institute of Antler Science and Product Technology,Changchun Sci-Tech University,Changchun 130000,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China;National Laboratory of Biomacromolecules,CAS Center for Excellence in Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;Department of Orthopaedics,Peking University First Hospital,Beijing 100034,China;Gene Expression Laboratory,Salk Institute for Biological Studies,La Jolla,CA,USA

蛋白质与细胞

[1]Jinghui Lei;Xiaoyu Jiang;Wei Li;Jie Ren;Datao Wang;Zhejun Ji;Zeming Wu;Fang Cheng;Yusheng Cai;Zheng-Rong Yu;Juan Carlos Izpisua Belmonte;Chunyi Li;Guang-Hui Liu;Weiqi Zhang;Jing Qu;Si Wang-.Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis)[J].蛋白质与细胞,2022(03):220-226

Stem,Damaser

Exosomes,from,antler,stem,cells,alleviate,mesenchymal,senescence,osteoarthritis,Dear,Editor,therapy,holds,enormous,revolutionary,promise,treat,various,age,related,diseases,such,diabetes,heart,failure,Parkinson,However,low,retention,survival,rate,delivered,partially,due,immuno,logical,rejection,constitute,major,hurdles,clinical,implementation,Lei,2021a,Since,mounting,evidence,showed,that,several,types,mainly,exert,their,therapeutic,effects,through,secretion,paracrine,exosomes,which,are,released,by,execute,most,functions,have,begun,draw,attention,field,Tran

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