Dear Editor, The interventions that slow aging or promote healthy aging may provide preventative measures for age-related diseases(Zhang et al.,2015).Therefore,it is crucial to identify drugs that target aging-related pathologies and improve health-span in geroscience research.Using model organisms such as C.elegans and rodents,several small molecules capable of alleviating the onset or progression of aging,including rapamycin,nicotinamide mononucleotide,and metformin,have been discovered(Partridge et al.,2020).However,the safety and efficacy of these chemicals still need in-depth evaluation before clinical applications(Partridge et al.,2020).As a result,it is necessary to identify additional compounds with geroprotective effects for human cells to counteract the general trend of populational aging.However,transforming a promising compound into an approved drug requires enormous resources.Alternatively,repurposing previously approved drugs for new clinical applications offers a more efficient and less costly path toward drug develop-ment.Therefore,testing U.S.Food and Drug Administration(FDA)-approved drugs for geroprotective effects may dis-covernew therapeutics that have already been stringently tested in humans for safety.

Hezhen Shan;Lingling Geng;Xiaoyu Jiang;Moshi Song;Jianxun Wang;Zunpeng Liu;Xiao Zhuo;Zeming Wu;Jianli Hu;Zhejun Ji;Si Wang;Piu Chan;Jing Qu;Weiqi Zhang;Guang-Hui Liu

State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;Advanced Innovation Center for Human Brain Protection,National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Aging Translational Medicine Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;University of Chinese Academy of Sciences,Beijing 100049,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;China National Center for Bioinformation,Beijing 100101,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;Sino-Danish College,University of Chinese Academy of Sciences,Beijing 101408,China

蛋白质与细胞

[1]Hezhen Shan;Lingling Geng;Xiaoyu Jiang;Moshi Song;Jianxun Wang;Zunpeng Liu;Xiao Zhuo;Zeming Wu;Jianli Hu;Zhejun Ji;Si Wang;Piu Chan;Jing Qu;Weiqi Zhang;Guang-Hui Liu-.Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells)[J].蛋白质与细胞,2022(07):532-539

geroprotector,geroscience,Partridge,geroprotective,populational,covernew,stringently

Large,scale,screen,identifies,Gallic,acid,stem,cells,Dear,Editor, The,interventions,that,slow,aging,promote,healthy,may,provide,preventative,measures,age,related,diseases,Zhang,Therefore,crucial,identify,drugs,target,pathologies,improve,span,research,Using,model,organisms,such,elegans,rodents,several,small,molecules,capable,alleviating,onset,progression,including,rapamycin,nicotinamide,mononucleotide,metformin,have,been,discovered,However,safety,efficacy,these,chemicals,still,need,depth,evaluation,before,clinical,applications,result,necessary,additional,compounds,effects,counteract,general,trend,transforming,promising,into,approved,requires,enormous,resources,Alternatively,repurposing,previously,offers,more,efficient,less,costly,toward,develop,ment,testing,Food,Drug,Administration,FDA,therapeutics,already,tested,humans

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