Dear Editor, N6-methyladenosine(m6A)is an abundant epitranscriptomic modification that regulates messenger RNA(mRNA)biology.The m6A modification regulates mRNA splicing,transport,stability,and translation through coordinated activities by methyltransferases(writers),binding proteins(readers),and demethylases(erasers)(Huang et al.,2020;Wu et al.,2020).Among m6A regulators,fat mass of obesity-associ-ated protein(FTO),is the first discovered eraser with RNA m6A demethylation activity(Jia et al.,2011).Since then,FTO has been reported to play m6A-dependent roles in a variety of physiological processes including adipogenesis,neuro-genesis and tumorigenesis(Fischer et al.,2009;Li et al.,2017;Huang et al.,2020).Consequently,FTO deficiency in mice leads to dramatic phenotypes,such as decreased fat mass and impaired brain development(Fischer et al.,2009;Li et al.,2017).Similarly,inhibition of FTO reduces tumori-genesis in multiple types of cancer models,while FTO is highly expressed in many cancers(Huang et al.,2020).

Sheng Zhang;Zeming Wu;Yue Shi;Si Wang;Jie Ren;Zihui Yu;Daoyuan Huang;Kaowen Yan;Yifang He;Xiaoqian Liu;Qianzhao Ji;Beibei Liu;Zunpeng Liu;Jing Qu;Guang-Hui Liu;Weimin Ci;Xiaoqun Wang;Weiqi Zhang

State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Brain-Intelligence Technology(Shanghai),Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China;CAS Key Laboratory of Genomic and Precision Medicine,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100101,China;China National Center for Bioinformation,Beijing 100101,China;Advanced Innovation Center for Human Brain Protection,and National Clinical Research Center for Geriatric Disorders,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Aging Translational Medicine Center,International Center for Aging and Cancer,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Chongqing Renji Hospital,University of Chinese Academy of Sciences,Chongqing 400062,China;Sino-Danish College,University of Chinese Academy of Sciences,Beijing 101408,China;State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Beijing Institute for Brain Disorders,Beijing 100069,China

蛋白质与细胞

[1]Sheng Zhang;Zeming Wu;Yue Shi;Si Wang;Jie Ren;Zihui Yu;Daoyuan Huang;Kaowen Yan;Yifang He;Xiaoqian Liu;Qianzhao Ji;Beibei Liu;Zunpeng Liu;Jing Qu;Guang-Hui Liu;Weimin Ci;Xiaoqun Wang;Weiqi Zhang-.FTO stabilizes MIS12 and counteracts senescence)[J].蛋白质与细胞,2022(12):954-960

MIS12, N6,epitranscriptomic,erasers,eraser

FTO,stabilizes,counteracts,senescence,Dear,Editor,methyladenosine,m6A,abundant,modification,that,regulates,messenger,biology,splicing,transport,stability,translation,through,coordinated,activities,by,methyltransferases,writers,binding,proteins,readers,demethylases,Huang,Wu,Among,regulators,fat,mass,obesity,associ,first,discovered,demethylation,activity,Jia,Since,then,has,been,reported,play,dependent,roles,variety,physiological,processes,including,adipogenesis,neuro,tumorigenesis,Fischer,Li,Consequently,deficiency,mice,leads,dramatic,phenotypes,such,decreased,impaired,brain,development,Similarly,inhibition,reduces,multiple,models,while,highly,expressed,many,cancers

0.570826