典型文献
Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis
文献摘要：
Dear Editor
Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(＞15 μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking.
文献关键词：
中图分类号：
作者姓名：
Xiaolong Ma;Jiacheng Deng;Lulu Han;Yuwei Song;Yutong Miao;Xing Du;Guohui Dang;Dongmin Yang;Bitao Zhong;Changtao Jiang;Wei Kong;Qingbo Xu;Juan Feng;Xian Wang
作者机构：
Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Peking University,Beijing 100191,China;Cardiovascular Division,BHF Center of Vascular Regeneration,King's College London,London,UK;Department of Clinical Laboratory,Beijing Chao-Yang Hospital,Capital Medical University,Beijing 100020,China;Department of Cardiology,The First Affiliated Hospital,Zhejiang University,Hangzhou 310003,China
文献出处：
引用格式：
[1]Xiaolong Ma;Jiacheng Deng;Lulu Han;Yuwei Song;Yutong Miao;Xing Du;Guohui Dang;Dongmin Yang;Bitao Zhong;Changtao Jiang;Wei Kong;Qingbo Xu;Juan Feng;Xian Wang-.Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis)[J].蛋白质与细胞,2022(07):540-547
A类：
adventitia,
Cardiovascular,Truelsen,hyperhomocys,teinemia
B类：
Single,cell,sequencing,reveals,interactions,hyperhomocysteinemia,accelerated,atherosclerosis,Dear,Editor,disease,CVD,leading,death,around,world,Atherosclerosis,dominant,underlying,chronic,characterized,by,lipid,accumulation,immune,infiltration,plaques,vessels,Weber,microenvironment,critical,development,Homocysteine,intermediate,product,methionine,metabolism,vation,plasma,known,HHcy,independent,risk,more,common,Asia,because,genetic,factors,dietary,habits,Huo,folic,acid,supplement,one,most,important,way,treat,clinic,Although,potentiates,mainly,through,endothelial,injury,inflammatory,activa,Luo,comprehensive,understanding,potential,mechanisms,atherosclerotic,aortas,AA,still,lacking
AB值：
0.554042
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