典型文献
Maternally loaded RNAs:no time to die
文献摘要：
Upon fertilization,the animal genome is often inactive and development is driven by proteins and transcripts that are stored in the egg during oogenesis.In a recent Cell Research paper,Shi et al.show that the RNA helicase Ddx3xb facilitates the translation of stored transcripts in zebrafish embryos by a phase separation-dependent process.
The development of animal embryos is initially directed by maternally provided proteins and RNAs.Developmental control is gradually handed over to the embryo during the maternal-to-zygotic transition,when the zygotic genome is activated.1 To ensure a successful change from the maternal to the zygotic gene expression program,maternal transcripts are degraded during this transition.The changes in gene expression are precisely controlled and highly interconnected(Fig.1).In zebrafish,for example,the translation of maternally loaded RNAs is required to activate zygotic transcription,while the zygotic transcription of a micro-RNA is required to initiate the degradation of many maternal transcripts.This raises an interesting conundrum:maternally loaded RNAs need to be translated before they are degraded.
文献关键词：
中图分类号：
作者姓名：
Martino Ugolini;Nadine L.Vastenhouw
作者机构：
Center for Integrative Genomics(CIG),University of Lausanne(UNIL),Lausanne,Switzerland
文献出处：
引用格式：
[1]Martino Ugolini;Nadine L.Vastenhouw-.Maternally loaded RNAs:no time to die)[J].细胞研究（英文版）,2022(08):707-708
A类：
oogenesis,Ddx3xb
B类：
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The,initially,directed,maternally,provided,Developmental,gradually,handed,over,zygotic,transition,when,activated,To,ensure,successful,from,expression,program,degraded,this,changes,precisely,controlled,highly,interconnected,Fig,example,required,transcription,while,micro,initiate,degradation,many,This,raises,interesting,conundrum,need,translated,before,they
AB值：
0.514992
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