典型文献
Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos
文献摘要：
The Dux gene plays an important role in mouse embryo develop-ment(De laco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic devel-opment.Approximately 11-100 copies of the DUX4 gene form a tan-dem cluster in the human genome(Snider et al.,2009,2010).Because of the lack of available embryos and efficient methods for DUX4 gene manipulation,the function of DUX4 in human embryos has not been clearly elucidated.
文献关键词：
中图分类号：
作者姓名：
Yubing Liu;Xinmei Lu;Min Ye;Ling Wang;Rongxin Tang;Zhiyong Yang;Bongkoch Turathum;Chenchen Liu;Yujing Xue;Menghua Wu;Yannan Yang;Ermeng Gao;Di Zhang;Feng Yang;Keh-Kooi Kee;Xingxu Huang;Guanglei Li;Ri-Cheng Chian
作者机构：
Center for Reproductive Medicine,Tenth People's Hospital of Tongji University,301 Middle Yanchang Road,Shanghai 200072,China;Center for Reproductive Medicine,Zhongshan Hospital,Fudan University,180 Fenglin Road,Shanghai 200032,China;Center for Stem Cell Biology and Regenerative Medicine,Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China;Department of Basic Medical Science,Faculty of Medicine Vajira Hospital,Navamindradhiraj University,Bangkok 10300,Thailand;School of Life Science and Technology,Shanghai Tech University,100 Haike Road,Pudong New Area,Shanghai 201210,China
文献出处：
引用格式：
[1]Yubing Liu;Xinmei Lu;Min Ye;Ling Wang;Rongxin Tang;Zhiyong Yang;Bongkoch Turathum;Chenchen Liu;Yujing Xue;Menghua Wu;Yannan Yang;Ermeng Gao;Di Zhang;Feng Yang;Keh-Kooi Kee;Xingxu Huang;Guanglei Li;Ri-Cheng Chian-.Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos)[J].遗传学报,2022(10):982-985
A类：
multicopy,Dux,laco,Hendrickson,Whiddon
B类：
Efficient,silencing,DUX4,gene,by,ABE,mediated,start,codon,mutation,human,embryos,plays,important,role,mouse,develop,De,It,participates,maternal,zygotic,transition,MTZ,which,mainly,includes,transcript,degradation,genome,activation,ZGA,is,key,process,embryonic,opment,Approximately,copies,form,dem,cluster,Snider,Because,lack,available,efficient,methods,manipulation,function,has,not,been,clearly,elucidated
AB值：
0.546627
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
