典型文献
APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes
文献摘要：
Among the risk factors for late onset sporadic Alzheimer's disease (AD) is the expression of ε4 allele of apolipoprotein E (APOE4) gene (Mahley et al., 2006). Elevated amyloid processing and reduced degradation of Aβ, which lead to Aβ plaque deposition, are evident in APOE4-positive AD patients and mice (Mahley et al., 2006). These features correlate with neuronal cell loss. Impaired mitochondrial activity and increased oxidative stress have long been recognized as additional hallmarks of AD pathology (Mahley et al., 2006). The effect of APOE4 expression on autophagy and mitochondrial dynamics and activity in astrocytes is discussed in this perspective and is summarized in Figure 1.
文献关键词：
中图分类号：
作者姓名：
Schmukler Eran
作者机构：
Department of Neurobiology,School of Neurobiology Biochemistry and Biophysics,Tel-Aviv University,Ramat-Aviv,Israel
文献出处：
引用格式：
[1]Schmukler Eran-.APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes)[J].中国神经再生研究（英文版）,2022(04):777-778
A类：
Mahley
B类：
APOE4,expression,associated,impaired,autophagy,mitophagy,astrocytes,Among,risk,factors,onset,sporadic,Alzheimer,disease,AD,allele,apolipoprotein,gene,Elevated,amyloid,processing,reduced,degradation,which,lead,plaque,deposition,are,evident,positive,patients,mice,These,features,correlate,neuronal,cell,loss,Impaired,mitochondrial,activity,increased,oxidative,stress,have,long,been,recognized,additional,hallmarks,pathology,effect,dynamics,discussed,this,perspective,summarized,Figure
AB值：
0.596263
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
