典型文献
Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy
文献摘要：
Photodynamic therapy (PDT), which utilizes light excite photosensitizers (PSs) to generate reactive oxygen species (ROS) and consequently ablate cancer cells or diseased tissue, has attracted a great deal of attention in the last decades due to its unique advantages. However, the advancement of PDT is restricted by the inherent characteristics of PS and tumor microenvironment (TME). It is urgent to explore high-performance PSs with TME regulation capability and subsequently improve the therapeutic outcomes. Herein, we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic anticancer therapy. Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxidative stress in TME, which could be further amplified under light irradiation. Excellent in vitro and in vivo PDT effects were achieved due to the improved ROS (hydroxyl radicals and singlet oxygen) generation efficiency, hypoxia relief, and glutathione depletion. Moreover, the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.
文献关键词：
中图分类号：
作者姓名：
Liyun Lin;Wen Pang;Xinyan Jiang;Shihui Ding;Xunbin Wei;Bobo Gu
作者机构：
Med-X Research Institute and School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China;Biomedical Engineering Department,Peking University,Beijing 100081,China;Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Peking University Cancer Hospital&Institute,Beijing 100142,China
文献出处：
引用格式：
[1]Liyun Lin;Wen Pang;Xinyan Jiang;Shihui Ding;Xunbin Wei;Bobo Gu-.Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy)[J].光：科学与应用（英文版）,2022(03):341-356
A类：
CHNPs
B类：
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AB值：
0.642406
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