典型文献
Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy
文献摘要：
Riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural pho-tosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by its poor cellular uptake.In this study,using cell-penetrating peptides Arg8,(Cha-Arg)3 and small molecule triphenylphosphine(TPP)as delivery compounds,three RF conjugates were prepared to increase the accumulation of RF in cells,termed as Arg8-RF,(Cha-Arg)3-RF and TPP-RF,respectively.Compared with TPP-RF and Arg8-RF(Cha-Arg)3-RF exhibited better cell internalization and stronger cy-totoxicity against HeLa cells upon exposure to blue light.Further researches proved that(Cha-Arg)3-RF generated reactive oxygen species(ROS)under irradiation,which could indiscriminately destroy endoge-nous proteins and mitochondria,ultimately inducing cell death.This work provides a new approach to explore RF as a natural photosensitizer for antitumor photodynamic therapy.
文献关键词：
中图分类号：
作者姓名：
Chunlei Wu;Yanyan Li;Zhehong Cheng;Pengxin Wang;Zhilong Ma;Ke Liu;Yulian Cheng;Yimin Zhou;Xian Lin;Ximing Shao;Yong Yang;Hongchang Li;Lijing Fang
作者机构：
Guangdong Key Laboratory of Nanomedicine,Institute of Biomedicine and Biotechnology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;University of Chinese Academy of Sciences,Beijing 100049,China;Department of Biomedical Engineering,Southern University of Science and Technology(SUSTech),Shenzhen 518055,China
文献出处：
引用格式：
[1]Chunlei Wu;Yanyan Li;Zhehong Cheng;Pengxin Wang;Zhilong Ma;Ke Liu;Yulian Cheng;Yimin Zhou;Xian Lin;Ximing Shao;Yong Yang;Hongchang Li;Lijing Fang-.Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy)[J].中国化学快报（英文版）,2022(09):4339-4344
A类：
tosensitizer,Arg8,triphenylphosphine,totoxicity,indiscriminately
B类：
Cell,penetrating,riboflavin,antitumor,photodynamic,therapy,Riboflavin,RF,vitamin,B2,essential,has,been,considered,promising,natural,PDT,However,further,exploration,application,was,limited,by,its,poor,cellular,uptake,In,this,study,using,peptides,Cha,small,molecule,TPP,delivery,compounds,three,conjugates,were,prepared,increase,accumulation,cells,termed,respectively,Compared,exhibited,better,internalization,stronger,cy,against,HeLa,upon,exposure,blue,light,Further,researches,proved,that,generated,reactive,oxygen,species,ROS,under,irradiation,which,could,destroy,endoge,nous,proteins,mitochondria,ultimately,inducing,death,This,work,provides,new,approach,explore,photosensitizer
AB值：
0.590316
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