典型文献
Breaking-then-curing strategy for efficient cystic echinococcosis therapy
文献摘要：
Cystic echinococcosis(CE)is one of the most harmful and life-threatening helminths.As the essential therapeutics,chemotherapy is always difficult to achieve desired anti-echinococcal effect due to the prob-lems that the echinococcus granulosus cyst laminated layer makes the drug difficult to infiltrate and the poor solubility of drugs.In this study,we established a"breaking-then-curing"anti-echinococcal treat-ment strategy for efficient CE therapy.The photodynamic therapy(PDT)was used as a breaker to pro-duce toxic reactive oxygen species(ROS)and damage the laminated layer of protoscolices(PSCs),leading to enhanced infiltration of albendazole sulfoxide nanoparticles(ABZSO NPs).Then,ABZSO NP was worked as curer for efficient anti-echinococcal treatment.As a result,the breaking-then-curing treatment strat-egy could generate more intracellular ROS in PSCs induced by plenty of ABZSO NPs,greatly increasing the mortality rate of PSCs in a shorter time than using ABZSO NPs alone,leading to the attenuation of lam-inated layer and finally disintegrating PSCs.We believe the"breaking-then-curing"strategy will suggest great potential in the treatment of CE and provide a new sight for anti-echinococcal treatment.
文献关键词：
中图分类号：
作者姓名：
Tianjiao Zhou;Yuan Xu;Yuehong Gong;Mingtao Yu;Enzhen Xu;Wusimanjiang Aimaiti;Ruijia Ma;Lei Xing;Hao Wen;Jianhua Wang;Hulin Jiang
作者机构：
State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China;State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Medical University,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;College of Pharmaceutical Sciences,Xinjiang Medical University,Urumqi 830011,China
文献出处：
引用格式：
[1]Tianjiao Zhou;Yuan Xu;Yuehong Gong;Mingtao Yu;Enzhen Xu;Wusimanjiang Aimaiti;Ruijia Ma;Lei Xing;Hao Wen;Jianhua Wang;Hulin Jiang-.Breaking-then-curing strategy for efficient cystic echinococcosis therapy)[J].中国化学快报（英文版）,2022(06):2949-2953
A类：
echinococcal,echinococcus,protoscolices,ABZSO,curer,disintegrating
B类：
Breaking,then,curing,strategy,efficient,cystic,echinococcosis,Cystic,CE,most,harmful,life,threatening,helminths,essential,therapeutics,chemotherapy,always,difficult,achieve,desired,anti,effect,due,prob,lems,that,granulosus,laminated,layer,makes,infiltrate,poor,solubility,drugs,In,this,study,we,established,breaking,photodynamic,PDT,was,used,breaker,toxic,reactive,oxygen,species,ROS,damage,PSCs,leading,enhanced,infiltration,albendazole,sulfoxide,nanoparticles,NPs,Then,worked,treatment,result,could,generate,more,intracellular,induced,by,plenty,greatly,increasing,mortality,shorter,than,using,alone,attenuation,finally,We,believe,will,suggest,potential,provide,new,sight
AB值：
0.486306
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