Conventional anti-Stokes materials-involved deep photodynamic therapy(dPDT)requires much high-intensity irradiance due to low photosensitization efficiency.Herein,we proposed a"booster effector"approach to construct highly efficient hot band absorption phototherapeutics for low/biosafety power anti-Stokes light-triggered dPDT.Se,as"booster effector",was introduced into hot band absorption luminophores(HBAs),which not only significantly facilitated intersystem crossing,but also si-multaneously enhanced hot band excitation efficiency at v808,as a result successfully enabling excellent photogenerated singlet oxygen capability of HBAs under ultra-low power anti-Stokes excitation(10 mW cm-2 in vitro).As far as we know,such low laser power-initiated photosensitization activity has never been reported in the existing anti-Stokes material systems.Im-portantly,FUC-SeME can self-assemble into uniform nanospheres in water,greatly boosting cellular uptake(＞25-fold larger than FUC-Se),and achieve superior cancer-killing effect(808 nm,10 mW cm-2,5 min,the half-maximal inhibitory con-centration IC50=1.36 μM).After further PEGylation with folate-attached polymer,the resultant FUC-SeME@FA can effec-tively enrich at the tumor(signal-to-background ratio,10).Under safety irradiation(330 mW cm-2),FUC-SeME@FA effectively inhibits deep-seated tumor progression(the tumor growth inhibition rate,84％).This work provides a successful paradigm,possibly being more clinically beneficial than conventional anti-Stokes materials.

State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China;Shenzhen Research Institute,Dalian University of Technology,Shenzhen 518057,China;Institute of Molecular Sciences and Engineering,Institute of Frontier and Interdisciplinary Science,Shandong University,Qingdao 266237,China;Department of Chemistry,Korea University,Seoul 02841,Republic of Korea;Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China

[1]Dandan Ma;Hui Bian;Saran Long;Panwang Zhou;Ruisong Tian;Yingnan Wu;Haoying Ge;Mingle Li;Jianjun Du;Jiangli Fan;Yukui Zhang;Xiaojun Peng-.Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy)[J].中国科学:化学（英文版）,2022(03):563-573

dPDT,phototherapeutics,HBAs,multaneously,v808,SeME

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