典型文献
Sonodynamic cancer therapy by novel iridium-gold nanoassemblies
文献摘要：
Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic per-formance.But,low in-depth tissue penetration of light limits their effectivity for deeply buried tumors.Encouraged by the sonosensitizing ability of the traditional organic photosensitizers,here,we developed AuNPs@Ir1 as a sonosensitizer by hybridizing an organometallic Ir(Ⅲ)complex(Ir1)with ultrasmall gold nanoparticles(AuNPs)for efficient tumor sonodynamic therapy(SDT)for the first time.AuNPs@Ir1 rapidly entered the cancer cells,produced 1O2,and catalytically oxidized NADH to NAD+under ultrasound(US)irradiation,thus resulted in cancer cells oncosis.Because of efficient passive retention in tumors post in-travenous injection,AuNPs@Ir1 further efficiently inhibited the growth of tumors in-vivo under US stim-ulation without long-term toxicity to other organs.Overall,this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel AuNPs@Ir1.It is expected to increase the scope of SDT for metal-based anticancer drugs.
文献关键词：
中图分类号：
作者姓名：
Jiayi Zhu;Ai Ouyang;Zhuanglin Shen;Zhihao Pan;Samya Banerjee;Qianling Zhang;Yantao Chen;Pingyu Zhang
作者机构：
College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518060,China;College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518060,China;Department of Chemistry,Indian Institute of Technology(BHU),Varanasi,UP 221005,India
文献出处：
引用格式：
[1]Jiayi Zhu;Ai Ouyang;Zhuanglin Shen;Zhihao Pan;Samya Banerjee;Qianling Zhang;Yantao Chen;Pingyu Zhang-.Sonodynamic cancer therapy by novel iridium-gold nanoassemblies)[J].中国化学快报（英文版）,2022(04):1907-1912
A类：
nanoassemblies,photochemotherapeutic,Encouraged,sonosensitizing,NAD+under,oncosis,travenous
B类：
Sonodynamic,therapy,by,novel,iridium,gold,Metal,compounds,excellent,physical,properties,show,good,formance,But,low,depth,tissue,penetration,light,limits,their,effectivity,deeply,buried,tumors,ability,traditional,organic,photosensitizers,here,we,developed,AuNPs,Ir1,sonosensitizer,hybridizing,organometallic,complex,ultrasmall,nanoparticles,sonodynamic,SDT,first,rapidly,entered,cells,produced,1O2,catalytically,oxidized,NADH,ultrasound,US,irradiation,thus,resulted,Because,passive,retention,post,injection,further,efficiently,inhibited,growth,vivo,stim,ulation,without,long,term,toxicity,organs,Overall,this,work,presents,triggered,vitro,anticancer,profile,It,expected,increase,scope,drugs
AB值：
0.576397
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