典型文献
A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy
文献摘要：
During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug resistance.Therefore,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing an activable platform is promising for precise and efficient anticancer treatment.Herein,we report a"pro-drug-photosensitizer"agent,LMB-S-CPT,bearing a disulfide bond as the glu-tathione(GSH)-activatable linker.LMB-S-CPT can be selectively activated by GSH to release activated drug,camptothecin(CPT),for chemotherapy and activated photosensitizer,methylene blue(MB),for PDT.LMB-S-CPT exhibits excellent tumor-activatable performance when injected into tumor-bearing mice,as well as specific cancer therapy with negligible toxic side effects.The activatable pro-drug-photosensitizer offers a new strategy for chemo-photodynamic therapy and displays precise,selective and excellent antitumor effect.
文献关键词：
中图分类号：
作者姓名：
Yanjun Yang;Yifeng Zhang;Ran Wang;Xiang Rong;Ting Liu;Xiang Xia;Jiangli Fan;Wen Sun;Xiaojun Peng
作者机构：
State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China;Ningbo Institute of Dalian University of Technology,Ningbo 315016,China
文献出处：
引用格式：
[1]Yanjun Yang;Yifeng Zhang;Ran Wang;Xiang Rong;Ting Liu;Xiang Xia;Jiangli Fan;Wen Sun;Xiaojun Peng-.A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy)[J].中国化学快报（英文版）,2022(10):4583-4586
A类：
cheomtherapy,activable
B类：
glutathione,activatable,photosensitizer,combined,chemotherapy,photodynamic,During,treatment,chemotherapeutic,drugs,always,result,severe,side,effects,resistance,Therefore,combining,modalities,such,PDT,designing,platform,promising,precise,efficient,anticancer,Herein,report,agent,LMB,CPT,bearing,disulfide,bond,GSH,linker,selectively,activated,by,release,camptothecin,methylene,blue,exhibits,excellent,performance,when,injected,into,mice,well,specific,negligible,toxic,offers,new,strategy,displays,antitumor
AB值：
0.473129
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