To develop smart and efficient near-infrared(NIR) organic dyes for photothermal cancer therapy is of great challenge.Herein,a pH-sensitive NIR dye BTN with donor-acceptor-donor scaffold has been synthesized.Two periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer (PET),but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer (ICT) under acidic circum-stance.Through enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000 (DSPE-mPEG2000),BTN nanoparticles (NPs) were fabricated with robust NIR absorption covering 600-900 nm,excellent photothermal conversion efficiency (43.2％),and good photostability.Additionally,BTN NPs can selectively target lysosomes.Through tailing intravenous injection into tumor-bearing nude mice,BTN NPs demonstrate outstanding photoa-coustic/photothermal/fluorescence imaging-guided pho-tothermal therapy for tumor ablation.

Xin-Yu Qu;Ying Hong;Han Cai;Xu Sun;Qing Shen;Dong-Liang Yang;Xiao-Chen Dong;Ai-Hong Jiao;Peng Chen;Jin-Jun Shao

(C)Key Laboratory of Flexible Electronics and Institute of Advanced Materials,Nanjing Tech University,Nanjing 211800,China;(C)School of Chemistry and Materials Science,Nanjing University of Information Science and Technology,Nanjing 210044,China;(C)Department of Oncology,the Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,China;(C)School of Chemical and Biomedical Engineering,Nanyang Technological University,Singapore 637459,Singapore

稀有金属（英文版）

[1]Xin-Yu Qu;Ying Hong;Han Cai;Xu Sun;Qing Shen;Dong-Liang Yang;Xiao-Chen Dong;Ai-Hong Jiao;Peng Chen;Jin-Jun Shao-.Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy)[J].稀有金属（英文版）,2022(01):56-66

distearoyl,photoa,coustic

Promoted,intramolecular,photoinduced,electron,transfer,multi,mode,imaging,guided,cancer,photothermal,therapy,To,develop,smart,efficient,near,infrared,NIR,organic,dyes,great,challenge,Herein,sensitive,BTN,donor,acceptor,scaffold,has,been,synthesized,Two,periphery,donating,dimethylamine,groups,not,only,promote,PET,but,also,bind,protons,transform,into,deficient,ammonium,cation,enhanced,charge,ICT,under,acidic,circum,stance,Through,enveloping,amphiphilic,polymeric,ras,glycerol,phosphatidyl,ethanolamine,polyethyleneglycol,DSPE,mPEG2000,nanoparticles,NPs,were,fabricated,robust,absorption,covering,excellent,conversion,efficiency,good,photostability,Additionally,selectively,target,lysosomes,tailing,intravenous,injection,tumor,bearing,nude,mice,demonstrate,outstanding,fluorescence,ablation

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