典型文献
A sulfur-substituted hemicyanine for cancer photothermal therapy without influence of intracellular viscosity
文献摘要：
Although photothermal therapy(PTT)has emerged as an appealing strategy for cancer treatment,the development of photo-thermal agents capable of precisely controlling temperature remains a challenge.In this paper,we present a novel synthetic photosensitizer based on a sulfur-substituted hemicyanine.It was discovered that replacing an oxygen atom in a hemicyanine derivative with a sulfur atom significantly enhances photothermal efficiency and enables lysosome targeting in cancer cells.More importantly,because of the rigid planer structure of the sulfur-substituted hemicyanine,which differs from traditional photothermal agents(PTAs)based on twisted intramolecular charge transfer(TICT)or group rotation mechanisms,the effi-ciency of photothermal conversion is not affected by intracellular viscosity,allowing precise temperature control during PTT.Further modifying the agent with a glutathione-responsive moiety allows the PTAs to be activated only in cancer cells.The newly proposed PTA achieves efficient PTT in a tumor-bearing mouse model while having negligible toxic side effects on healthy tissues.
文献关键词：
中图分类号：
作者姓名：
Xiang Xia;Ran Wang;Yingqi Hu;Qichao Yao;Saran Long;Wen Sun;Jiangli Fan;Xiaojun Peng
作者机构：
State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China;Ningbo Institute of Dalian University of Technology,Ningbo 315016,China
文献出处：
引用格式：
[1]Xiang Xia;Ran Wang;Yingqi Hu;Qichao Yao;Saran Long;Wen Sun;Jiangli Fan;Xiaojun Peng-.A sulfur-substituted hemicyanine for cancer photothermal therapy without influence of intracellular viscosity)[J].中国科学:化学（英文版）,2022(04):821-828
A类：
hemicyanine,planer
B类：
sulfur,substituted,cancer,photothermal,therapy,without,influence,intracellular,viscosity,Although,PTT,has,emerged,appealing,strategy,treatment,development,agents,capable,precisely,controlling,temperature,remains,challenge,In,this,paper,we,present,novel,synthetic,photosensitizer,It,was,discovered,that,replacing,oxygen,atom,derivative,significantly,enhances,efficiency,enables,lysosome,targeting,cells,More,importantly,because,rigid,structure,which,differs,from,traditional,PTAs,twisted,intramolecular,charge,transfer,TICT,group,rotation,mechanisms,conversion,not,affected,by,allowing,during,Further,modifying,glutathione,responsive,moiety,allows,activated,only,newly,proposed,achieves,efficient,tumor,bearing,mouse,model,while,having,negligible,toxic,side,effects,healthy,tissues
AB值：
0.608775
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