典型文献
Injectable self-healing polysaccharide hydrogel loading CuS and pH-responsive DOX@ZIF-8 nanoparticles for synergistic photothermal-photodynamic-chemo therapy of cancer
文献摘要：
The injectable self-healing polysaccharide hydrogel was prepared by the formation of Schiff base bonds between aldehyde-modified methylcellulose(MC-CHO)and carboxymethyl chitosan(CMC).The copper sulfide nanoparticles(CuS NPs)and pH-sensitive doxorubicin-loaded zeolitic imidazolate frameworks nanoparticles(DOX@ZIF-8 NPs)were prepared and could be well-dispersed into the hydrogel system.The presence of CuS NPs can achieve photothermal therapy(PTT)for tumors under the irradiation of the near-infrared(NIR)laser.Moreover,CuS NPs can generate photodynamic effects under NIR irradia-tion,converting oxygen into toxic reactive oxygen species(ROS)and presenting efficient photodynamic therapy(PDT).The DOX@ZIF-8 NPs can be decomposed under an intracellular acidic environment and re-alize the controlled release of DOX.The injectable self-healing hydrogel loading CuS and DOX@ZIF-8 NPs can achieve synergistic photothermal-photodynamic-chemo therapy for tumors and will inspire the re-searchers to construct a platform from hydrogel combined with multifunctional nanomaterials to realize the effective multimodal therapy for tumor.
文献关键词：
中图分类号：
作者姓名：
Zhiyi Qian;Nuoya Zhao;Chunyao Wang;Weizhong Yuan
作者机构：
School of Materials Science and Engineering,Key Laboratory of Advanced Civil Materials of Ministry of Education,Tongji University,Shanghai 201804,China;Beijing Research Institute of Chemical Industry(BRICI),Sinopec,Beijing 100013,China
文献出处：
引用格式：
[1]Zhiyi Qian;Nuoya Zhao;Chunyao Wang;Weizhong Yuan-.Injectable self-healing polysaccharide hydrogel loading CuS and pH-responsive DOX@ZIF-8 nanoparticles for synergistic photothermal-photodynamic-chemo therapy of cancer)[J].材料科学技术（英文版）,2022(32):245-255
A类：
alize
B类：
Injectable,self,healing,polysaccharide,hydrogel,loading,CuS,responsive,DOX,ZIF,nanoparticles,synergistic,photothermal,photodynamic,chemo,therapy,cancer,injectable,was,prepared,by,formation,Schiff,base,bonds,between,aldehyde,modified,methylcellulose,CHO,carboxymethyl,chitosan,CMC,copper,sulfide,NPs,sensitive,doxorubicin,loaded,zeolitic,imidazolate,frameworks,were,could,well,dispersed,into,system,presence,achieve,PTT,tumors,under,irradiation,near,infrared,NIR,laser,Moreover,generate,effects,converting,oxygen,toxic,reactive,species,ROS,presenting,efficient,PDT,decomposed,intracellular,acidic,environment,controlled,release,will,inspire,searchers,construct,platform,from,combined,multifunctional,nanomaterials,realize,effective,multimodal
AB值：
0.536808
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