典型文献
Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy
文献摘要：
Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment.In this task,we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy,which is prepared via a hollow ZIF-8(where ZIF is zeolitic imidazolate frameworks)coated by the Eu3+-doped mesoporous silica(ZIF-8@mesoporous silica).The hollow ZIF-8 is used as a drug library for loading the anticancer drug,and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal cells.The shell layer of mesoporous silica can achieve the long-term drug release,which solves the problem of short drug circulation time in the body,reduces the drug administration fre-quency,and improves the therapeutic effect.Notably,the ZIF-8@mesoporous+doxorubicin(DOX)is injected only once during the 14-day chemotherapy.In addition,Eu3+-doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living cells.Hence,this nanoplatform provides a whole new strategy for the long-term treatment of tumors.
文献关键词：
中图分类号：
作者姓名：
Lu-Min Wang;Wen-Yan Liu;Ming-Liang Hu;Jia-Sai Yao;Ping Wang;Jia-Hao Liu;Miao He;Yi Gao;Zhen-Xing Li
作者机构：
Gastroenterology Department,The Second Affiliated Hospital of Xi'an Jiaotong University,,Xi'an 710004,China;Digestive Diseases in Precision Medicine Institute,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China;State Key Laboratory of Heavy Oil Processing,College of New Energy and Materials,China University of Petroleum(Beijing),Beijing 102249,China
文献出处：
引用格式：
[1]Lu-Min Wang;Wen-Yan Liu;Ming-Liang Hu;Jia-Sai Yao;Ping Wang;Jia-Hao Liu;Miao He;Yi Gao;Zhen-Xing Li-.Rare earth-based MOF@mesoporous silica nanoplatform for long-term and luminescence trackable chemotherapy)[J].稀有金属（英文版）,2022(08):2701-2710
A类：
trackable,poisonousness,mesoporous+doxorubicin
B类：
Rare,earth,MOF,silica,nanoplatform,long,term,luminescence,chemotherapy,Developing,multifunctional,nanocarriers,release,traceability,challenging,assignment,In,this,task,we,designed,novel,which,prepared,via,hollow,ZIF,where,zeolitic,imidazolate,frameworks,coated,by,Eu3+,doped,used,library,loading,anticancer,sensitive,properties,targeted,drugs,cut,down,normal,cells,shell,layer,achieve,solves,problem,short,circulation,body,reduces,administration,fre,quency,improves,therapeutic,effect,Notably,DOX,injected,only,once,during,day,addition,ensures,tracking,detection,pathways,living,Hence,provides,whole,new,strategy,treatment,tumors
AB值：
0.507789
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