典型文献
Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery
文献摘要：
Since self-assembled peptide hydrogels can solve the problems such as low solubility,poor selectivity and serious adverse effects of traditional chemotherapy drugs,they have been widely used as carrier materials for drug delivery.In this study,we developed a novel and injectable drug delivery platform for the antitumor drug doxorubicin(DOX)using a pH-responsive ionic-complementary octapeptide FOE.This octapeptide could self-assemble into stable hydrogel under neutral conditions,while disassemble un-der the tumor microenvironment.Especially,at pH 5.8,its micromorphology displayed a transition from nanofibers to nanospheres with the change of secondary structure,which enhanced cellular uptake of DOX.In addition,FOE hydrogel serves as a smart drug reservoir by localized injection to achieve sus-tained drug release and improve antitumor efficacy.This octapeptide opens up new avenues for promot-ing the clinical translation of anticancer drugs on account of excellent injectable properties and economic benefits of simple and short sequence.
文献关键词：
中图分类号：
作者姓名：
Jie Li;Zhongshi Wang;Han Han;Zhonghua Xu;Shasha Li;Ying Zhu;Yuejian Chen;Liang Ge;Yuan Zhang
作者机构：
Department of Orthopedics,Xinqiao Hospital,Army Medical University,Chongqing 400038,China;State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China;School of Pharmacy,Xinjiang Medical University,Urumqi 830054,China;Nanjing aifarui Pharmaceutical Technology Co.,Ltd.,Nanjing 210009,China
文献出处：
引用格式：
[1]Jie Li;Zhongshi Wang;Han Han;Zhonghua Xu;Shasha Li;Ying Zhu;Yuejian Chen;Liang Ge;Yuan Zhang-.Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery)[J].中国化学快报（英文版）,2022(04):1936-1940
A类：
octapeptide,FOE,disassemble
B类：
Short,simple,sensitive,antitumor,delivery,Since,self,assembled,hydrogels,solve,problems,such,low,solubility,poor,selectivity,serious,adverse,effects,traditional,chemotherapy,drugs,they,have,been,widely,used,carrier,materials,In,this,study,we,developed,novel,injectable,platform,doxorubicin,DOX,using,responsive,ionic,complementary,This,could,into,stable,under,neutral,conditions,while,microenvironment,Especially,micromorphology,displayed,transition,from,nanofibers,nanospheres,change,secondary,structure,which,enhanced,cellular,uptake,addition,serves,smart,reservoir,by,localized,injection,achieve,sus,tained,release,improve,efficacy,opens,new,avenues,promot,clinical,translation,anticancer,account,excellent,properties,economic,benefits,short,sequence
AB值：
0.616571
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
