典型文献
An endoplasmic reticulum-targeted organic photothermal agent for enhanced cancer therapy
文献摘要：
Developing selectively targeted photothermal agents to reduce side effects in photothermal therapy re-mains a great challenge.Inspired by the key role of endoplasmic reticulum in the protein synthesis and intracellular signal transduction,particularly for the immunogenic cell death induced by endoplasmic reticulum stress,we developed an endoplasmic reticulum-targeted organic photothermal agent(Ts-PT-RGD)for enhancing photothermal therapy of tumor.The photothermal agent was covalently attached with 4-methylbenzenesulfonamide and cyclic Arg-Gly-Asp(cRGD)peptide for realizing the targeting of endoplasmic reticulum and tumor cell.Owing to its amphiphilic properties,it readily self-assembles in water to form nanoparticles.The photothermal agent possesses excellent photophysical properties and biological compatibility.In vitro and in vivo experiments demonstrate that it can actively target endoplas-mic reticulum and effectively ablate tumor with near-infrared laser.
文献关键词：
中图分类号：
作者姓名：
Kaiye Wang;Yanan Xiang;Wei Pan;Hongyu Wang;Na Li;Bo Tang
作者机构：
College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Collaborative Innovation Centre of Functionalized Probes for Chemical Imaging in Universities of Shandong,Institute of Molecular and Nano Science,Shandong Normal University,Ji'nan 250014,China
文献出处：
引用格式：
[1]Kaiye Wang;Yanan Xiang;Wei Pan;Hongyu Wang;Na Li;Bo Tang-.An endoplasmic reticulum-targeted organic photothermal agent for enhanced cancer therapy)[J].中国化学快报（英文版）,2022(02):793-797
A类：
methylbenzenesulfonamide,endoplas
B类：
An,endoplasmic,reticulum,targeted,organic,photothermal,enhanced,cancer,therapy,Developing,selectively,agents,reduce,side,effects,mains,great,challenge,Inspired,by,key,role,protein,synthesis,intracellular,signal,transduction,particularly,immunogenic,death,induced,stress,we,developed,Ts,PT,enhancing,tumor,was,covalently,attached,cyclic,Arg,Gly,Asp,cRGD,peptide,realizing,targeting,Owing,its,amphiphilic,properties,readily,self,assembles,water,form,nanoparticles,possesses,excellent,photophysical,biological,compatibility,vitro,vivo,experiments,demonstrate,that,actively,effectively,ablate,near,infrared,laser
AB值：
0.575022
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