Bacterial cellulose(BC)is one of the most versatile natural biopolymers with unique physical,chemical,and biological features.However,the lack of intrinsic antibacterial property of native BC limits its broad biomedical applications where such property is highly required to prevent contamination or infection caused by attached bacteria.In this work,we developed a simple and facile method to fabricate a dual-functional BC membrane by physical incorporation of gold nanorods(GNRs)followed by deposition of a phase-transitioned bovine serum albumin(PTB)film.Due to the broad-spectrum antifouling property of the PTB film,the resulting membrane could prevent the adhesion and accumulation of bacteria.A few bacteria that broke through the protection of the PTB film could be eradicated under short-term irradia-tion of a near-infrared laser due to the excellent photothermal property of incorporated GNRs.The whole fabrication was conducted in a simple and environmentally friendly manner,avoiding complicated pro-cesses and toxic organic solvents.Moreover,because all the components were biocompatible,the result-ing membrane showed negligible cytotoxicity in vitro and good histocompatibility in vivo.This work thus provided a reliable way to endow BC with antibacterial property,being beneficial for diverse biomedical applications.

Luohuizi Li;Guize Li;Yong Wu;Yuancheng Lin;Yangcui Qu;Yan Wu;Kunyan Lu;Yi Zou;Hong Chen;Qian Yu;Yanxia Zhang

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China;Institute for Cardiovascular Science and Department of Cardiovascular Surgery of the First Affiliated Hospital,Soochow University,Suzhou 215007,China;College of Biomedical Engineering&the Key Laboratory for Medical Functional Nanomaterials,Jining Medical University,Jining 272067,China

材料科学技术（英文版）

[1]Luohuizi Li;Guize Li;Yong Wu;Yuancheng Lin;Yangcui Qu;Yan Wu;Kunyan Lu;Yi Zou;Hong Chen;Qian Yu;Yanxia Zhang-.Dual-functional bacterial cellulose modified with phase-transitioned proteins and gold nanorods combining antifouling and photothermal bactericidal properties)[J].材料科学技术（英文版）,2022(15):14-23

Dual,functional,cellulose,modified,phase,transitioned,proteins,gold,nanorods,combining,antifouling,photothermal,bactericidal,properties,Bacterial,BC,most,versatile,natural,biopolymers,unique,physical,chemical,biological,features,However,lack,intrinsic,antibacterial,property,native,limits,broad,biomedical,applications,where,such,highly,required,prevent,contamination,infection,caused,by,attached,In,this,work,developed,simple,facile,method,fabricate,dual,membrane,incorporation,GNRs,followed,deposition,bovine,serum,albumin,PTB,film,Due,spectrum,resulting,could,adhesion,accumulation,few,that,broke,through,protection,eradicated,under,short,term,irradia,near,infrared,laser,due,excellent,incorporated,whole,fabrication,was,conducted,environmentally,friendly,manner,avoiding,complicated,cesses,organic,solvents,Moreover,because,components,were,biocompatible,showed,negligible,cytotoxicity,vitro,good,histocompatibility,vivo,This,thus,provided,reliable,way,endow,being,beneficial,diverse

0.645861