典型文献
Human islet amyloid polypeptide:A therapeutic target for the management of type 2 diabetes mellitus
文献摘要：
Type 2 diabetes mellitus(T2DM)and other metabolic disorders are often silent and go unnoticed in patients because of the lack of suitable prognostic and diagnostic markers.The current therapeutic regimens available for managing T2DM do not reverse diabetes;instead,they delay the progression of diabetes.Their efficacy(in principle)may be significantly improved if implemented at earlier stages.The misfolding and aggregation of human islet amyloid polypeptide(hIAPP)or amylin has been associated with a gradual decrease in pancreatic β-cell function and mass in patients with T2DM.Hence,hIAPP has been recognized as a therapeutic target for managing T2DM.This review summarizes hIAPP's role in mediating dysfunction and apoptosis in pancreatic β-cells via induction of endoplasmic reticulum stress,oxidative stress,mitochondrial dysfunction,inflammatory cytokine secretion,autophagy blockade,etc.Furthermore,it explores the possibility of using intermediates of the hIAPP aggregation pathway as potential drug targets for T2DM management.Finally,the effects of common antidiabetic molecules and repurposed drugs;other hIAPP mimetics and peptides;small organic molecules and natural compounds;nanoparticles,nanobodies,and quantum dots;metals and metal complexes;and chaperones that have demonstrated potential to inhibit and/or reverse hIAPP aggregation and can,therefore,be further developed for managing T2DM have been discussed.
文献关键词：
中图分类号：
作者姓名：
Pratiksha H.Roham;Shreyada N.Save;Shilpy Sharma
作者机构：
Department of Biotechnology,Savitribai Phule Pune University,Ganeshkhind,41100,India
文献出处：
引用格式：
[1]Pratiksha H.Roham;Shreyada N.Save;Shilpy Sharma-.Human islet amyloid polypeptide:A therapeutic target for the management of type 2 diabetes mellitus)[J].药物分析学报（英文）,2022(04):556-569
A类：
amylin
B类：
Human,islet,amyloid,polypeptide,therapeutic,management,type,diabetes,mellitus,Type,T2DM,other,metabolic,disorders,are,often,silent,go,unnoticed,patients,because,lack,suitable,prognostic,diagnostic,markers,current,regimens,available,managing,reverse,instead,they,delay,progression,Their,efficacy,principle,may,significantly,improved,implemented,earlier,stages,misfolding,aggregation,human,hIAPP,has,been,associated,gradual,decrease,pancreatic,mass,Hence,recognized,This,review,summarizes,role,mediating,dysfunction,apoptosis,cells,via,induction,endoplasmic,reticulum,stress,oxidative,mitochondrial,inflammatory,cytokine,secretion,autophagy,blockade,etc,Furthermore,explores,possibility,using,intermediates,pathway,potential,targets,Finally,effects,common,antidiabetic,molecules,repurposed,drugs,mimetics,peptides,small,organic,natural,compounds,nanoparticles,nanobodies,quantum,dots,metals,complexes,chaperones,that,have,demonstrated,inhibit,therefore,further,developed,discussed
AB值：
0.618536
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
