典型文献
Injectable composite hydrogel based on carbon particles for photothermal therapy of bone tumor and bone regeneration
文献摘要：
Surgical resection,as the most efficient treatment for bone tumor,still faces a dilemma between the com-plete removal of tumor tissue and the maximum reservation of healthy bone tissue.In response to this,an injectable composite hydrogel with chitosan/hyaluronic acid/β-sodium glycerophosphate as the matrix and carbon particles as the photothermal agent is developed.Owing to the temperature sensitivity,the composite hydrogel can be injected into the irregular bone defect and exhibit the sol-gel phase transition upon body temperature,facilitating the conformal therapy.The composite hydrogel can ablate the human osteosarcoma on Balb/c nude mice model with the tumor inhibition rate of 98.4％after near-infrared laser irradiation(808 nm).The assessment of bone regeneration on calvarial-defect model of Sprague-Dawley rats reveals that the composite hydrogel can promote new bone formation with the bone volume/total volume ratio of 76.2％after 8 weeks,in sharp contrast to the control group of 23.9％.
文献关键词：
中图分类号：
作者姓名：
Chengxiong Wei;Xin Jin;Chengwei Wu;Wei Zhang
作者机构：
State Key Laboratory of Structure Analysis for Industrial Equipment,Department of Engineering Mechanics,Dalian University of Technology,Dalian 116024,China
文献出处：
引用格式：
[1]Chengxiong Wei;Xin Jin;Chengwei Wu;Wei Zhang-.Injectable composite hydrogel based on carbon particles for photothermal therapy of bone tumor and bone regeneration)[J].材料科学技术（英文版）,2022(23):64-72
A类：
glycerophosphate
B类：
Injectable,composite,hydrogel,carbon,particles,photothermal,therapy,bone,tumor,regeneration,Surgical,resection,most,efficient,treatment,still,faces,dilemma,between,plete,removal,tissue,maximum,reservation,healthy,response,this,injectable,chitosan,hyaluronic,acid,sodium,matrix,agent,developed,Owing,temperature,sensitivity,can,injected,into,irregular,defect,exhibit,sol,phase,transition,upon,body,facilitating,conformal,ablate,human,osteosarcoma,Balb,nude,mice,model,inhibition,rate,after,near,infrared,laser,irradiation,assessment,calvarial,Sprague,Dawley,rats,reveals,that,promote,new,formation,volume,total,weeks,sharp,contrast,control,group
AB值：
0.590973
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
