典型文献
A Therapeutic Sheep in Metastatic Wolf's Clothing:Trojan Horse Approach for Cancer Brain Metastases Treatment
文献摘要：
Early-stage brain metastasis of breast cancer(BMBC),due to the existence of an intact blood-brain barrier(BBB),is one of the deadliest neurologic complications.To improve the efficacy of chemotherapy for BMBC,a Trojan horse strategy-based nanocarrier has been developed by integrating the cell membrane of a brain-hom-ing cancer cell and a polymeric drug depot.With the camouflage of a MDA-MB-231/Br cell membrane,doxorubicin-loaded poly(D,L-lac-tic-co-glycolic acid)nanoparticle(DOX-PLGA@CM)shows enhanced cellular uptake and boosted killing potency for MDA-MB-231/Br cells.Furthermore,DOX-PLGA@CM is equipped with naturally selected molecules for BBB penetration,as evidenced by its boosted capacity in entering the brain of both healthy and early-stage BMBC mouse mod-els.Consequently,DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain,slows down cancer progression,reduces tumor burden,and extends the survival time for the BMBC animal.Furthermore,the simplicity and easy scale-up of the design opens a new window for the treatment of BMBC and other brain metastatic cancers.
文献关键词：
中图分类号：
作者姓名：
Hai-jun Liu;Mingming Wang;Shanshan Shi;Xiangxiang Hu;Peisheng Xu
作者机构：
Department of Drug Discovery and Biomedical Sciences,College of Pharmacy,University of South Carolina,Columbia,SC 29208,USA
文献出处：
引用格式：
[1]Hai-jun Liu;Mingming Wang;Shanshan Shi;Xiangxiang Hu;Peisheng Xu-.A Therapeutic Sheep in Metastatic Wolf's Clothing:Trojan Horse Approach for Cancer Brain Metastases Treatment)[J].纳微快报（英文）,2022(07):140-156
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AB值：
0.655784
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